e-Drug3D
315
DIPYRIDAMOLE
INN
DIPYRIDAMOLE
cas 58-32-2
CLASS
BLOOD
CORONARY VASODILATOR
PHOSPHODIESTERASE INHIBITORS
ANTIPLATELET AGENT
INHIBITS THE UPTAKE OF ADENOSINE INTO PLATELETS
ROUTE (list)
ORAL INJECTION
ATC code
B01AC07
PK parameters
Tmax 2 HOUR
VD 92 LITER
Cl 4.6 LITER / HOUR (EQN)
PPB 99 PERCENT
t1/2 13.6 HOUR
Solubility
PRACTICALLY INSOLUBLE IN WATER (LOGP=3.71)
TARGET PHOSPHODIESTERASE
PDB
8I4A (CRYO-EM STRUCTURE OF DIPYRIDAMOLE-BOUND ABCC4)
Ligand code = H9F (link to the list of PDB complexes)
Download experimental 3D coordinates of H9F with added hydrogens
cGMP-specific 3,5-cyclic phosphodiesterase UNIPROT O76074 PDE5A
cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase 10A UNIPROT Q9Y233 PDE10A
Formula:
C24H40N8O4
Calculated chemical properties:
MW 504.64
NB_atoms 36
XLogP -0.02
PSA 126.864
NB_HD 4
NB_HA 12
fsp3 0.75
Lipinski(0=no;1=yes) 0
NB_atoms 36
XLogP -0.02
PSA 126.864
NB_HD 4
NB_HA 12
fsp3 0.75
Lipinski(0=no;1=yes) 0
FDA
NDA 089425 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (PUREPAC PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089426 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (PUREPAC PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 012836 (label) INN (DIPYRIDAMOLE) PERSANTINE (BOEHRINGER INGELHEIM) APPROVAL= AP YEAR= 1961 DISCONTINUED
NDA 087184 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (BARR) APPROVAL= AP YEAR= 1980
NDA 086944 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (ANI PHARMS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 087160 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (WATSON LABS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 087716 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (BARR) APPROVAL= AP YEAR= 1984
NDA 087717 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (BARR LABS) APPROVAL= AP YEAR= 1987
NDA 088999 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (GLENMARK GENERICS) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 019817 (pdf not found) INN (DIPYRIDAMOLE) IV PERSANTINE (BOEHRINGER INGELHEIM) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 089000 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (GLENMARK GENERICS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 089001 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (GLENMARK GENERICS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 087561 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (IDT AUSTRALIA LTD) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 087562 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (IDT AUSTRALIA LTD) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 074521 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (HIKMA) APPROVAL= AP YEAR= 1996
NDA 074601 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (HOSPIRA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074952 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (DR REDDYS) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074939 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (CHARTWELL INJECTABLE) APPROVAL= AP YEAR= 1998
NDA 074956 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 020884 (label) INN (ASPIRIN ; DIPYRIDAMOLE) AGGRENOX (BOEHRINGER INGELHEIM) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 089427 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (PUREPAC PHARM) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075769 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (EUGIA PHARMA SPECLTS) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 040542 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (OXFORD PHARMS) APPROVAL= AP YEAR= 2006
NDA 040733 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (RISING) APPROVAL= AP YEAR= 2007
NDA 040782 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (IMPAX LABS) APPROVAL= AP YEAR= 2007
NDA 040874 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (ZYDUS PHARMS USA INC) APPROVAL= AP YEAR= 2008
NDA 040898 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (CHARTWELL RX) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078804 (pdf not found) INN (ASPIRIN ; DIPYRIDAMOLE) ASPIRIN AND DIPYRIDAMOLE (BARR) APPROVAL= AP YEAR= 2009
NDA 206392 (pdf not found) INN (ASPIRIN ; DIPYRIDAMOLE) ASPIRIN AND DIPYRIDAMOLE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2016
NDA 206739 (pdf not found) INN (ASPIRIN ; DIPYRIDAMOLE) ASPIRIN AND DIPYRIDAMOLE (SANDOZ) APPROVAL= AP YEAR= 2017
NDA 206964 (pdf not found) INN (ASPIRIN ; DIPYRIDAMOLE) ASPIRIN AND DIPYRIDAMOLE (ANI PHARMS) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 207944 (pdf not found) INN (ASPIRIN ; DIPYRIDAMOLE) ASPIRIN AND DIPYRIDAMOLE (PAR PHARM INC) APPROVAL= AP YEAR= 2017
NDA 206753 (pdf not found) INN (ASPIRIN ; DIPYRIDAMOLE) ASPIRIN AND DIPYRIDAMOLE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2017
NDA 208572 (pdf not found) INN (ASPIRIN ; DIPYRIDAMOLE) ASPIRIN AND DIPYRIDAMOLE (SUN PHARM) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 209048 (pdf not found) INN (ASPIRIN ; DIPYRIDAMOLE) ASPIRIN AND DIPYRIDAMOLE (DR REDDYS) APPROVAL= AP YEAR= 2018
NDA 204552 (pdf not found) INN (ASPIRIN ; DIPYRIDAMOLE) ASPIRIN AND DIPYRIDAMOLE (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 210318 (pdf not found) INN (ASPIRIN ; DIPYRIDAMOLE) ASPIRIN AND DIPYRIDAMOLE (GLENMARK SPECLT) APPROVAL= AP YEAR= 2019
NDA 209929 (pdf not found) INN (ASPIRIN ; DIPYRIDAMOLE) ASPIRIN AND DIPYRIDAMOLE (MICRO LABS) APPROVAL= AP YEAR= 2021
NDA 089425 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (PUREPAC PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089426 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (PUREPAC PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 012836 (label) INN (DIPYRIDAMOLE) PERSANTINE (BOEHRINGER INGELHEIM) APPROVAL= AP YEAR= 1961 DISCONTINUED
NDA 087184 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (BARR) APPROVAL= AP YEAR= 1980
NDA 086944 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (ANI PHARMS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 087160 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (WATSON LABS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 087716 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (BARR) APPROVAL= AP YEAR= 1984
NDA 087717 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (BARR LABS) APPROVAL= AP YEAR= 1987
NDA 088999 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (GLENMARK GENERICS) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 019817 (pdf not found) INN (DIPYRIDAMOLE) IV PERSANTINE (BOEHRINGER INGELHEIM) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 089000 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (GLENMARK GENERICS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 089001 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (GLENMARK GENERICS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 087561 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (IDT AUSTRALIA LTD) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 087562 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (IDT AUSTRALIA LTD) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 074521 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (HIKMA) APPROVAL= AP YEAR= 1996
NDA 074601 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (HOSPIRA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074952 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (DR REDDYS) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074939 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (CHARTWELL INJECTABLE) APPROVAL= AP YEAR= 1998
NDA 074956 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 020884 (label) INN (ASPIRIN ; DIPYRIDAMOLE) AGGRENOX (BOEHRINGER INGELHEIM) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 089427 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (PUREPAC PHARM) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075769 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (EUGIA PHARMA SPECLTS) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 040542 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (OXFORD PHARMS) APPROVAL= AP YEAR= 2006
NDA 040733 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (RISING) APPROVAL= AP YEAR= 2007
NDA 040782 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (IMPAX LABS) APPROVAL= AP YEAR= 2007
NDA 040874 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (ZYDUS PHARMS USA INC) APPROVAL= AP YEAR= 2008
NDA 040898 (pdf not found) INN (DIPYRIDAMOLE) DIPYRIDAMOLE (CHARTWELL RX) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078804 (pdf not found) INN (ASPIRIN ; DIPYRIDAMOLE) ASPIRIN AND DIPYRIDAMOLE (BARR) APPROVAL= AP YEAR= 2009
NDA 206392 (pdf not found) INN (ASPIRIN ; DIPYRIDAMOLE) ASPIRIN AND DIPYRIDAMOLE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2016
NDA 206739 (pdf not found) INN (ASPIRIN ; DIPYRIDAMOLE) ASPIRIN AND DIPYRIDAMOLE (SANDOZ) APPROVAL= AP YEAR= 2017
NDA 206964 (pdf not found) INN (ASPIRIN ; DIPYRIDAMOLE) ASPIRIN AND DIPYRIDAMOLE (ANI PHARMS) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 207944 (pdf not found) INN (ASPIRIN ; DIPYRIDAMOLE) ASPIRIN AND DIPYRIDAMOLE (PAR PHARM INC) APPROVAL= AP YEAR= 2017
NDA 206753 (pdf not found) INN (ASPIRIN ; DIPYRIDAMOLE) ASPIRIN AND DIPYRIDAMOLE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2017
NDA 208572 (pdf not found) INN (ASPIRIN ; DIPYRIDAMOLE) ASPIRIN AND DIPYRIDAMOLE (SUN PHARM) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 209048 (pdf not found) INN (ASPIRIN ; DIPYRIDAMOLE) ASPIRIN AND DIPYRIDAMOLE (DR REDDYS) APPROVAL= AP YEAR= 2018
NDA 204552 (pdf not found) INN (ASPIRIN ; DIPYRIDAMOLE) ASPIRIN AND DIPYRIDAMOLE (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 210318 (pdf not found) INN (ASPIRIN ; DIPYRIDAMOLE) ASPIRIN AND DIPYRIDAMOLE (GLENMARK SPECLT) APPROVAL= AP YEAR= 2019
NDA 209929 (pdf not found) INN (ASPIRIN ; DIPYRIDAMOLE) ASPIRIN AND DIPYRIDAMOLE (MICRO LABS) APPROVAL= AP YEAR= 2021