e-Drug3D

307

VINBLASTINE

INN
VINBLASTINE

cas 865-21-4

CLASS

ANTINEOPLASTIC
ALKALOID EXTRACTED FROM VINCA ROSEA LINN
TUBULIN MODULATORS
INHIBITION OF MICROTUBULE FORMATION IN THE MITOTIC SPINDLE RESULTING IN AN ARREST OF DIVIDING CELLS AT THE METAPHASE STAGE

ROUTE (list)

INJECTION

ATC code

L01CA01

PK parameters

VD 1820 LITER (65 KILOGRAM)
Cl 12 LITER / HOUR (65 KILOGRAM)
PPB 86 PERCENT
t1/2 67 HOUR

Solubility

FREELY SOLUBLE IN WATER

Target

TARGET TUBULIN

PDB
4EB6 (TUBULIN-VINBLASTINE: STATHMIN-LIKE COMPLEX)

Ligand code = VLB (link to the list of PDB complexes)

Download experimental 3D coordinates of VLB with added hydrogens

DrugCentral

Tubulin beta UNIPROT P07437 TUBB

Download SDF file

1H-Indolizino[8,1-cd]carbazole-5-carboxylic acid, 4-(acetyloxy)-3a-ethyl-9-[5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-, methyl ester, [3aR-[3a.alpha.,4.beta.,5.beta.,5a.beta.,9(3R*,5S*,7R*,9S*),10bR*,13a.alpha.]]-

Formula:
C46H58N4O9

Calculated chemical properties:

MW 810.96
NB_atoms 59
XLogP 3.99
PSA 123.728
NB_HD 3
NB_HA 13
fsp3 0.59
Lipinski(0=no;1=yes) 0

FDA
NDA 089011 (pdf not found) INN (VINBLASTINE SULFATE) VINBLASTINE SULFATE (ABRAXIS PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089311 (pdf not found) INN (VINBLASTINE SULFATE) VINBLASTINE SULFATE (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089365 (pdf not found) INN (VINBLASTINE SULFATE) VINBLASTINE SULFATE (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 012665 (pdf not found) INN (VINBLASTINE SULFATE) VELBAN (LILLY) APPROVAL= AP YEAR= 1965 DISCONTINUED
NDA 089395 (pdf not found) INN (VINBLASTINE SULFATE) VINBLASTINE SULFATE (HIKMA) APPROVAL= AP YEAR= 1987
NDA 089515 (pdf not found) INN (VINBLASTINE SULFATE) VINBLASTINE SULFATE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1987
NDA 089565 (pdf not found) INN (VINBLASTINE SULFATE) VINBLASTINE SULFATE (HOSPIRA) APPROVAL= AP YEAR= 1987 DISCONTINUED