e-Drug3D

291

cas 64-86-8

CLASS

MUSCULO-SKELETAL
ANTIMITOTIC
INHIBITION OF BETA-TUBULIN POLYMERIZATION
ALKALOID
GOUT SUPPRESSANT

ROUTE (list)

ORAL

PK parameters

F 45 PERCENT
Tmax 1.5 HOUR
VD 341.5 LITER
Cl 54.1 LITER / HOUR
PPB 39 PERCENT
t1/2 28.9 HOUR

TARGET TUBULIN

PDB
4X1K (DISCOVERY OF CYTOTOXIC DOLASTATIN 10 ANALOGS WITH N-TERMINAL MODIFICATIONS)

Ligand code = LOC (link to the list of PDB complexes)

Download experimental 3D coordinates of LOC with added hydrogens

MW 399.43
NB_atoms 29
XLogP 2.87
PSA 84.227
NB_HD 1
NB_HA 7
fsp3 0.36
Lipinski(0=no;1=yes) 1

FDA
NDA 083720 (pdf not found) INN (COLCHICINE ; PROBENECID) PROBENECID AND COLCHICINE (IMPAX LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 012383 (pdf not found) INN (COLCHICINE ; PROBENECID) COLBENEMID (MERCK) APPROVAL= AP YEAR= 1961 DISCONTINUED
NDA 083221 (pdf not found) INN (COLCHICINE ; PROBENECID) PROBENECID W/ COLCHICINE (WATSON LABS) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 084279 (pdf not found) INN (COLCHICINE ; PROBENECID) COL-PROBENECID (WATSON LABS) APPROVAL= AP YEAR= 1976
NDA 084321 (pdf not found) INN (COLCHICINE ; PROBENECID) PROBENECID AND COLCHICINE (BEECHAM) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 085552 (pdf not found) INN (COLCHICINE ; PROBENECID) PROBEN-C (WATSON LABS) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 083734 (pdf not found) INN (COLCHICINE ; PROBENECID) PROBENECID AND COLCHICINE (ANI PHARMS) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 086954 (pdf not found) INN (COLCHICINE ; PROBENECID) PROBENECID W/ COLCHICINE (LEDERLE) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 086130 (pdf not found) INN (COLCHICINE ; PROBENECID) PROBENECID AND COLCHICINE (SANDOZ) APPROVAL= AP YEAR= 1980 DISCONTINUED
NDA 040618 (pdf not found) INN (COLCHICINE ; PROBENECID) PROBENECID AND COLCHICINE (NOVAST LABS) APPROVAL= AP YEAR= 2008
NDA 022351 (pdf not found) INN (COLCHICINE) COLCRYS (AR HOLDING CO INC) APPROVAL= AP YEAR= 2009
NDA 022352 (pdf not found) INN (COLCHICINE) COLCRYS (TAKEDA PHARMS USA) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 022353 (pdf not found) INN (COLCHICINE) COLCRYS (AR HOLDING CO INC) APPROVAL= AP YEAR= 2009
NDA 204820 (pdf not found) INN (COLCHICINE) MITIGARE (HIKMA INTL PHARMS) APPROVAL= AP YEAR= 2014
NDA 204711 (pdf not found) INN (COLCHICINE) COLCHICINE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2016
NDA 208678 (pdf not found) INN (COLCHICINE) COLCHICINE (PH HEALTH) APPROVAL= AP YEAR= 2018
NDA 204461 (pdf not found) INN (COLCHICINE) COLCHICINE (WATSON LABS INC) APPROVAL= AP YEAR= 2019
NDA 210942 (pdf not found) INN (COLCHICINE) GLOPERBA (SCILEX PHARMS) APPROVAL= AP YEAR= 2019
NDA 211250 (pdf not found) INN (COLCHICINE) COLCHICINE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2019
NDA 211519 (pdf not found) INN (COLCHICINE) COLCHICINE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2019
NDA 209470 (pdf not found) INN (COLCHICINE) COLCHICINE (MYLAN) APPROVAL= AP YEAR= 2019
NDA 209876 (pdf not found) INN (COLCHICINE) COLCHICINE (DR REDDYS) APPROVAL= AP YEAR= 2019
NDA 210425 (pdf not found) INN (COLCHICINE) COLCHICINE (GRANULES) APPROVAL= AP YEAR= 2020
NDA 203976 (pdf not found) INN (COLCHICINE) COLCHICINE (PH HEALTH) APPROVAL= AP YEAR= 2021
NDA 208993 (pdf not found) INN (COLCHICINE) COLCHICINE (HETERO LABS LTD V) APPROVAL= AP YEAR= 2021
NDA 209173 (pdf not found) INN (COLCHICINE) COLCHICINE (STRIDES PHARMA) APPROVAL= AP YEAR= 2022
NDA 215444 (pdf not found) INN (COLCHICINE) COLCHICINE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2022
NDA 215727 (pdf not found) INN (COLCHICINE) LODOCO (AGEPHA PHARMA FZ) APPROVAL= AP YEAR= 2023
NDA 217030 (pdf not found) INN (COLCHICINE ; PROBENECID) PROBENECID AND COLCHICINE (RISING) APPROVAL= AP YEAR= 2023
NDA 210757 (pdf not found) INN (COLCHICINE) COLCHICINE (GRANULES) APPROVAL= AP YEAR= 2024
NDA 215463 (pdf not found) INN (COLCHICINE) COLCHICINE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2024
NDA 217620 (pdf not found) INN (COLCHICINE) COLCHICINE (ANNORA PHARMA) APPROVAL= AP YEAR= 2024