e-Drug3D

286
DEXTROTHYROXINE

DISCONTINUED


INN
DEXTROTHYROXINE
cas 51-49-0
CLASS

CARDIOVASCULAR
ANTIHYPERLIPIDEMICS
ROUTE (list)

ORAL

ATC code

C10AX01
PK parameters

 Target

-

PDB
5CR1 (CRYSTAL STRUCTURE OF TTR, RESVERATROL, T4 COMPLEX)

Ligand code = T44 (link to the list of PDB complexes)

Download experimental 3D coordinates of T44 with added hydrogens

 DrugCentral

Thyroid hormone receptor UNIPROT P10827 THRA

 Download SDF file 2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid

Formula:
C15H11I4NO4

Calculated chemical properties:

MW 775.84
NB_atoms 24
XLogP 3.22
PSA 87.947
NB_HD 3
NB_HA 5
fsp3 0.13
Lipinski(0=no;1=yes) 0

FDA
NDA 012302 (pdf not found) INN (DEXTROTHYROXINE SODIUM) CHOLOXIN (ABBVIE) APPROVAL= AP YEAR= 1967 DISCONTINUED

 Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL