e-Drug3D

285

OXYTOCIN

INN
OXYTOCIN

cas 50-56-6

CLASS

HORMONES
OXYTOCIC
ANTI-TOCOLYTIC AGENTS
LABOR INDUCTION AGENTS

ROUTE (list)

NASAL INJECTION

ATC code

G02AC01
H01BB02

PK parameters

VD 33.2 LITER (PMID8568623)
Cl 85.2 LITER / HOUR (65 KILOGRAM) (PMID6486188)
t1/2 0.3 HOUR

Target

TARGET OXYTOCIN RECEPTOR (OTR)

PDB
1NPO (BOVINE NEUROPHYSIN II)

Ligand code = - (link to the list of PDB complexes)

Download experimental 3D coordinates of - with added hydrogens

DrugCentral

Oxytocin receptor UNIPROT P30559 OXTR

Download SDF file

(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide

Formula:
C43H66N12O12S2

Calculated chemical properties:

MW 1007.22
NB_atoms 69
XLogP -3.61
PSA 357.647
NB_HD 16
NB_HA 24
fsp3 0.60
Lipinski(0=no;1=yes) 0

FDA
NDA 012285 (pdf not found) INN (OXYTOCIN) SYNTOCINON (RTRX) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 018243 (pdf not found) INN (OXYTOCIN) OXYTOCIN (HIKMA) APPROVAL= AP YEAR= 1980
NDA 018245 (pdf not found) INN (OXYTOCIN) SYNTOCINON (NOVARTIS) APPROVAL= AP YEAR= 1980 DISCONTINUED
NDA 018248 (pdf not found) INN (OXYTOCIN) OXYTOCIN (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1980
NDA 018261 (pdf not found) INN (OXYTOCIN) PITOCIN (PH HEALTH) APPROVAL= AP YEAR= 1980
NDA 019185 (pdf not found) INN (OXYTOCIN) OXYTOCIN 5 USP UNITS IN DEXTROSE 5% (ABBOTT) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 077453 (pdf not found) INN (OXYTOCIN) OXYTOCIN (DR REDDYS) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 200219 (pdf not found) INN (OXYTOCIN) OXYTOCIN (HIKMA FARMACEUTICA) APPROVAL= AP YEAR= 2013
NDA 091676 (pdf not found) INN (OXYTOCIN) OXYTOCIN (SAGENT PHARMS INC) APPROVAL= AP YEAR= 2018