e-Drug3D
274
MEPIVACAINE
INN
MEPIVACAINE
cas 96-88-8
CLASS
NERVOUS SYSTEM
ANESTHETIC LOCAL
BLOCKER
ROUTE (list)
INJECTION
PK parameters
VD 61 LITER (65 KILOGRAM)
Cl 26 LITER / HOUR (65 KILOGRAM)
PPB 70 PERCENT
t1/2 2 HOUR
Solubility
SOLUBLE IN WATER
TARGET SODIUM CHANNEL PROTEIN
Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A
Sodium channel protein type 1 subunit alpha UNIPROT P35498 SCN1A
Formula:
C15H22N2O
Calculated chemical properties:
MW 246.35
NB_atoms 18
XLogP 2.73
PSA 29.911
NB_HD 1
NB_HA 3
fsp3 0.53
Lipinski(0=no;1=yes) 1
NB_atoms 18
XLogP 2.73
PSA 29.911
NB_HD 1
NB_HA 3
fsp3 0.53
Lipinski(0=no;1=yes) 1
FDA
NDA 012125 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) CARBOCAINE (EASTMAN KODAK) APPROVAL= AP YEAR= 1960 DISCONTINUED
NDA 012250 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) CARBOCAINE (HOSPIRA) APPROVAL= AP YEAR= 1960 DISCONTINUED
NDA 080925 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) ISOCAINE HYDROCHLORIDE (SEPTODONT) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 083559 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) MEPIVACAINE HYDROCHLORIDE (BELMORA LLC) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 084777 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) ARESTOCAINE HYDROCHLORIDE (SOLVAY) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 084697 (pdf not found) INN (LEVONORDEFRIN ; MEPIVACAINE HYDROCHLORIDE) ISOCAINE HYDROCHLORIDE W/ LEVONORDEFRIN (SEPTODONT) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 084850 (pdf not found) INN (LEVONORDEFRIN ; MEPIVACAINE HYDROCHLORIDE) MEPIVACAINE HYDROCHLORIDE W/ LEVONORDEFRIN (BELMORA LLC) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 085010 (pdf not found) INN (LEVONORDEFRIN ; MEPIVACAINE HYDROCHLORIDE) ARESTOCAINE HYDROCHLORIDE W/ LEVONORDEFRIN (SOLVAY) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 087509 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) MEPIVACAINE HYDROCHLORIDE (INTL MEDICATION SYS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 088387 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) SCANDONEST PLAIN (DEPROCO) APPROVAL= AP YEAR= 1984
NDA 088388 (pdf not found) INN (LEVONORDEFRIN ; MEPIVACAINE HYDROCHLORIDE) SCANDONEST L (DEPROCO) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088653 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) POLOCAINE (DENTSPLY PHARM) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088769 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) MEPIVACAINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088770 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) MEPIVACAINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 089406 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) POLOCAINE-MPF (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1986
NDA 089407 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) POLOCAINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1986
NDA 089408 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) POLOCAINE-MPF (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1986
NDA 089409 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) POLOCAINE-MPF (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1986
NDA 089410 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) POLOCAINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1986
NDA 089517 (pdf not found) INN (LEVONORDEFRIN ; MEPIVACAINE HYDROCHLORIDE) POLOCAINE W/ LEVONORDEFRIN (DENTSPLY PHARM) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 040806 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) MEPIVACAINE HYDROCHLORIDE (HOSPIRA INC) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 012125 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) CARBOCAINE (EASTMAN KODAK) APPROVAL= AP YEAR= 1960 DISCONTINUED
NDA 012250 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) CARBOCAINE (HOSPIRA) APPROVAL= AP YEAR= 1960 DISCONTINUED
NDA 080925 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) ISOCAINE HYDROCHLORIDE (SEPTODONT) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 083559 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) MEPIVACAINE HYDROCHLORIDE (BELMORA LLC) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 084777 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) ARESTOCAINE HYDROCHLORIDE (SOLVAY) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 084697 (pdf not found) INN (LEVONORDEFRIN ; MEPIVACAINE HYDROCHLORIDE) ISOCAINE HYDROCHLORIDE W/ LEVONORDEFRIN (SEPTODONT) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 084850 (pdf not found) INN (LEVONORDEFRIN ; MEPIVACAINE HYDROCHLORIDE) MEPIVACAINE HYDROCHLORIDE W/ LEVONORDEFRIN (BELMORA LLC) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 085010 (pdf not found) INN (LEVONORDEFRIN ; MEPIVACAINE HYDROCHLORIDE) ARESTOCAINE HYDROCHLORIDE W/ LEVONORDEFRIN (SOLVAY) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 087509 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) MEPIVACAINE HYDROCHLORIDE (INTL MEDICATION SYS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 088387 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) SCANDONEST PLAIN (DEPROCO) APPROVAL= AP YEAR= 1984
NDA 088388 (pdf not found) INN (LEVONORDEFRIN ; MEPIVACAINE HYDROCHLORIDE) SCANDONEST L (DEPROCO) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088653 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) POLOCAINE (DENTSPLY PHARM) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088769 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) MEPIVACAINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088770 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) MEPIVACAINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 089406 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) POLOCAINE-MPF (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1986
NDA 089407 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) POLOCAINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1986
NDA 089408 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) POLOCAINE-MPF (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1986
NDA 089409 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) POLOCAINE-MPF (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1986
NDA 089410 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) POLOCAINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1986
NDA 089517 (pdf not found) INN (LEVONORDEFRIN ; MEPIVACAINE HYDROCHLORIDE) POLOCAINE W/ LEVONORDEFRIN (DENTSPLY PHARM) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 040806 (pdf not found) INN (MEPIVACAINE HYDROCHLORIDE) MEPIVACAINE HYDROCHLORIDE (HOSPIRA INC) APPROVAL= AP YEAR= 2008 DISCONTINUED