e-Drug3D

258

cas 50-49-7

CLASS

NERVOUS SYSTEM
TRICYCLIC ANTIDEPRESSANT
NOREPINEPHRINE REUPTAKE INHIBITOR

ROUTE (list)

ORAL INJECTION

PK parameters

VD 828 LITER (65 KILOGRAM)
Cl 50.7 LITER / HOUR (65 KILOGRAM)
PPB 92.5 PERCENT
t1/2 16 HOUR

TARGET NORADRENALINE TRANSPORTER

PDB
2Q72 (CRYSTAL STRUCTURE ANALYSIS OF LEUT COMPLEXED WITH L-LEUCINE, SODIUM, AND IMIPRAMINE)

Ligand code = IXX (link to the list of PDB complexes)

Download experimental 3D coordinates of IXX with added hydrogens

MW 280.40
NB_atoms 21
XLogP 3.88
PSA 7.673
NB_HD 0
NB_HA 2
fsp3 0.37
Lipinski(0=no;1=yes) 1

FDA
NDA 084252 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 085220 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 085221 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 086765 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (NOVARTIS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088222 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (WEST WARD) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088223 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (WEST WARD) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 011836 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) PRESAMINE (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1959 DISCONTINUED
NDA 011838 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) TOFRANIL (NOVARTIS) APPROVAL= AP YEAR= 1959 DISCONTINUED
NDA 017090 (label) INN (IMIPRAMINE PAMOATE) TOFRANIL-PM (SPECGX LLC) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 017895 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) JANIMINE (ABBOTT) APPROVAL= AP YEAR= 1974 NEWAPPLICATION DISCONTINUED
NDA 083729 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (TEVA) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 083745 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 1976
NDA 084936 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 1976
NDA 084937 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 1976
NDA 083799 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (ROXANE) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 083827 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) PRAMINE (ALRA) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 085877 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 085878 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 085133 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 085200 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 085875 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 086267 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (LEDERLE) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 086268 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (LEDERLE) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 086269 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (LEDERLE) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 087619 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (VANGARD) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 087631 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (VANGARD) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 087776 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (USL PHARMA) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 088036 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (VANGARD) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 088262 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (STRIDES PHARMA) APPROVAL= AP YEAR= 1983
NDA 088276 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (STRIDES PHARMA) APPROVAL= AP YEAR= 1983
NDA 088292 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (STRIDES PHARMA) APPROVAL= AP YEAR= 1983
NDA 087844 (label) INN (IMIPRAMINE HYDROCHLORIDE) TOFRANIL (MALLINCKRODT INC) APPROVAL= AP YEAR= 1984 OBSOLETE
NDA 087845 (label) INN (IMIPRAMINE HYDROCHLORIDE) TOFRANIL (MALLINCKRODT INC) APPROVAL= AP YEAR= 1984 OBSOLETE
NDA 087846 (label) INN (IMIPRAMINE HYDROCHLORIDE) TOFRANIL (SPECGX LLC) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 084869 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 089422 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (PAR PHARM) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 089497 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (PAR PHARM) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 081048 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 081049 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1990
NDA 081050 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1990
NDA 040751 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (OXFORD PHARMS) APPROVAL= AP YEAR= 2008
NDA 040752 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (PROSAM LABS) APPROVAL= AP YEAR= 2008 DISCONTINUED OBSOLETE
NDA 040753 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (PROSAM LABS) APPROVAL= AP YEAR= 2008 DISCONTINUED OBSOLETE
NDA 090441 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (CHARTWELL) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 090442 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (LUPIN LTD) APPROVAL= AP YEAR= 2010 OBSOLETE
NDA 090443 (pdf not found) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (LUPIN LTD) APPROVAL= AP YEAR= 2010 OBSOLETE
NDA 090444 (pdf not found) INN (IMIPRAMINE PAMOATE) IMIPRAMINE PAMOATE (LUPIN LTD) APPROVAL= AP YEAR= 2010
NDA 091099 (pdf not found) INN (IMIPRAMINE PAMOATE) IMIPRAMINE PAMOATE (HIKMA) APPROVAL= AP YEAR= 2010
NDA 040903 (label) INN (IMIPRAMINE HYDROCHLORIDE) IMIPRAMINE HYDROCHLORIDE (LEADING) APPROVAL= AP YEAR= 2012
NDA 202338 (pdf not found) INN (IMIPRAMINE PAMOATE) IMIPRAMINE PAMOATE (RISING) APPROVAL= AP YEAR= 2013 DISCONTINUED