e-Drug3D

257

THIORIDAZINE


INN
THIORIDAZINE

cas 50-52-2
CLASS

NERVOUS SYSTEM
ANTIPSYCHOTIC
MANAGEMENT OF SCHIZOPHRENIC PATIENTS
ANXIOLYTIC
DOPAMINE ANTAGONISTS
PHENOTHIAZINES

ROUTE (list)

ORAL

ATC code

N05AC02

PK parameters

t1/2 15 HOUR

Target

TARGET DOPAMINE RECEPTOR
5-HYDROXYTRYPTAMINE 2A RECEPTOR
ALPHA-1A ADRENERGIC RECEPTOR

PDB
3TBG (HUMAN CYTOCHROME P450 2D6 WITH TWO THIORIDAZINES BOUND IN ACTIVE SITE)

Ligand code = RTZ (link to the list of PDB complexes)

Download experimental 3D coordinates of RTZ with added hydrogens

DrugCentral

D(2) dopamine receptor UNIPROT P14416 DRD2

Download SDF file 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine

Formula:
C21H26N2S2

Calculated chemical properties:

MW 370.58
NB_atoms 25
XLogP 5.89
PSA 8.34
NB_HD 0
NB_HA 2
fsp3 0.43
Lipinski(0=no;1=yes) 0

FDA
NDA 088284 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088296 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088322 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (PAR PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088323 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088336 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (PAR PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088345 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088351 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (PAR PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088352 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (PAR PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088381 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088410 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088412 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088480 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (PAR PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088658 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (WEST WARD) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088659 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (WEST WARD) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088660 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (WEST WARD) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088661 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (WEST WARD) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088663 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (ROXANE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088664 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (ROXANE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088665 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (ROXANE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089048 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (ROXANE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089764 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (PAR PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089765 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (PAR PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 011808 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) MELLARIL (NOVARTIS) APPROVAL= AP YEAR= 1962 DISCONTINUED
NDA 017923 (pdf not found) INN (THIORIDAZINE) MELLARIL-S (NOVARTIS) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 087264 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (MUTUAL PHARM) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 087766 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (ALPHARMA US PHARMS) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088004 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (MYLAN) APPROVAL= AP YEAR= 1983
NDA 088131 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088132 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088133 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088134 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088194 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088227 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (WOCKHARDT) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088229 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (ACTAVIS MID ATLANTIC) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088258 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (WOCKHARDT) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088270 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088271 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088272 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088273 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088370 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (MUTUAL PHARM) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088375 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (MUTUAL PHARM) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088379 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (MUTUAL PHARM) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088461 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088476 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (HERITAGE PHARMA AVET) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088477 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (WATSON LABS TEVA) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088478 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (HERITAGE PHARMA AVET) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088479 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (HERITAGE PHARMA AVET) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088135 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088307 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088308 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088332 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (MYLAN) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088333 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (MYLAN) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088334 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (MYLAN) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088335 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (MYLAN) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088561 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088562 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088563 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088564 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088567 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (WATSON LABS TEVA) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088736 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (HERITAGE PHARMA AVET) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088737 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088738 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088755 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088456 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 088493 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 088869 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 088872 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (WATSON LABS TEVA) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 088941 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE INTENSOL (ROXANE) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 088942 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE INTENSOL (ROXANE) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 089103 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (SUPERPHARM) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 089104 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (SUPERPHARM) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 089105 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (SUPERPHARM) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 088136 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 088137 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 089431 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (MUTUAL PHARM) APPROVAL= AP YEAR= 1986 OBSOLETE
NDA 089432 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (MUTUAL PHARM) APPROVAL= AP YEAR= 1986 OBSOLETE
NDA 089433 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (MUTUAL PHARM) APPROVAL= AP YEAR= 1986 OBSOLETE
NDA 089602 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 089603 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 089953 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 040125 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 040126 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 040187 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (PHARM ASSOC) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 040213 (pdf not found) INN (THIORIDAZINE HYDROCHLORIDE) THIORIDAZINE HYDROCHLORIDE (PHARM ASSOC) APPROVAL= AP YEAR= 1998 DISCONTINUED

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL