e-Drug3D

251

cas 554-57-4

CLASS

SENSORY
CARBONIC ANHYDRASE INHIBITORS
DIURETICS
LOWERING INTRAOCULAR PRESSURE

ROUTE (list)

ORAL

PK parameters

Tmax 1.5 HOUR
VD 20 LITER
Cl 0.99 LITER / HOUR (EQN)
PPB 55 PERCENT
t1/2 14 HOUR

TARGET CARBONIC ANHYDRASE

PDB
3DAZ (USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES)

Ligand code = MZM (link to the list of PDB complexes)

Download experimental 3D coordinates of MZM with added hydrogens

MW 236.29
NB_atoms 14
XLogP -1.42
PSA 101.698
NB_HD 2
NB_HA 7
fsp3 0.40
Lipinski(0=no;1=yes) 1

FDA
NDA 011721 (pdf not found) INN (METHAZOLAMIDE) NEPTAZANE (LEDERLE) APPROVAL= AP YEAR= 1959 DISCONTINUED
NDA 040001 (pdf not found) INN (METHAZOLAMIDE) METHAZOLAMIDE (ANI PHARMS) APPROVAL= AP YEAR= 1993
NDA 040036 (pdf not found) INN (METHAZOLAMIDE) METHAZOLAMIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1993
NDA 040062 (pdf not found) INN (METHAZOLAMIDE) METHAZOLAMIDE (MIKART) APPROVAL= AP YEAR= 1994
NDA 040102 (pdf not found) INN (METHAZOLAMIDE) METHAZOLAMIDE (ATHEM) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 040011 (pdf not found) INN (METHAZOLAMIDE) METHAZOLAMIDE (APPLIED ANAL) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 207438 (pdf not found) INN (METHAZOLAMIDE) METHAZOLAMIDE (BAUSCH AND LOMB INC) APPROVAL= AP YEAR= 2018
NDA 215615 (pdf not found) INN (METHAZOLAMIDE) METHAZOLAMIDE (TAGI) APPROVAL= AP YEAR= 2022