e-Drug3D

TUBOCURARINE

DISCONTINUED

INN
TUBOCURARINE

cas 57-95-4

CLASS

MUSCULO-SKELETAL
ALKALOID
NEUROMUSCULAR NONDEPOLARIZING AGENTS
INTERFERES WITH NICOTINIC ACETYLCHOLINE RECEPTOR (ACHR)
SKELETAL MUSCLE RELAXANTS

ROUTE (list)

INJECTION

ATC code

M03AA02

PK parameters

VD 29.2 LITER (65 KILOGRAM)
Cl 13.2 LITER / HOUR (65 KILOGRAM)
PPB 42 PERCENT
t1/2 2 HOUR

Target

TARGET 5-HYDROXYTRYPTAMINE 3 RECEPTOR (PMID16723497)

PDB
3PMZ (CRYSTAL STRUCTURE OF THE COMPLEX OF ACETYLCHOLINE BINDING PROTEIN AND D-TUBOCURARINE)

Ligand code = TUB (link to the list of PDB complexes)

Download experimental 3D coordinates of TUB with added hydrogens

DrugCentral

Acetylcholine receptor UNIPROT P02708 CHRNA1

Download SDF file

13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium, 2,3,13a,14,15,16,25,25a-octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-, (13aR,25aS)-

Formula:
C37H41N2O6

Calculated chemical properties:

MW 609.72
NB_atoms 45
XLogP 6.70
PSA 87.331
NB_HD 2
NB_HA 7
fsp3 0.35
Lipinski(0=no;1=yes) 0

FDA
NDA 089442 (pdf not found) INN (TUBOCURARINE CHLORIDE) TUBOCURARINE CHLORIDE (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 005657 (pdf not found) INN (TUBOCURARINE CHLORIDE) TUBOCURARINE CHLORIDE (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 1945 NEWMOLECULARENTITY DISCONTINUED
NDA 006095 (pdf not found) INN (TUBOCURARINE CHLORIDE) TUBOCURARINE CHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1947 DISCONTINUED
NDA 006325 (pdf not found) INN (TUBOCURARINE CHLORIDE) TUBOCURARINE CHLORIDE (LILLY) APPROVAL= AP YEAR= 1947 DISCONTINUED