e-Drug3D

249

cas 14838-15-4

CLASS

RESPIRATORY SYSTEM
APPETITE DEPRESSANTS
NASAL DECONGESTANTS
SYMPATHOMIMETICS
ALPHA-1 ADRENERGIC RECEPTOR PARTIAL AGONIST

ROUTE (list)

ORAL

PK parameters

Tmax 1.47 HOUR
VD 206.7 LITER (65 KILOGRAM)
Cl 37 LITER / HOUR
t1/2 4.05 HOUR

TARGET ALPHA-1 ADRENERGIC RECEPTOR

PDB
3U6K (EF-TU (ESCHERICHIA COLI) IN COMPLEX WITH NVP-LDK733)

Ligand code = BB8 (link to the list of PDB complexes)

Download experimental 3D coordinates of BB8 with added hydrogens

MW 151.20
NB_atoms 11
XLogP 1.07
PSA 43.057
NB_HD 3
NB_HA 2
fsp3 0.33
Lipinski(0=no;1=yes) 1

FDA
NDA 018115 (pdf not found) INN (CHLORPHENIRAMINE MALEATE ; PHENYLPROPANOLAMINE HYDROCHLORIDE) TRIAMINIC-12 (NOVARTIS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071099 (pdf not found) INN (PHENYLPROPANOLAMINE HYDROCHLORIDE) BROMATAPP (COPLEY PHARM) APPROVAL= AP YEAR= 0 DISCONTINUED OBSOLETE
NDA 088681 (pdf not found) INN (PHENYLPROPANOLAMINE HYDROCHLORIDE) CHLOROHENIRAMINE MALEATE AND PHENYLPROPANOLAMINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 0 DISCONTINUED OBSOLETE
NDA 088687 (pdf not found) INN (PHENYLPROPANOLAMINE HYDROCHLORIDE) BIPHETAP (MORTON GROVE) APPROVAL= AP YEAR= 0 DISCONTINUED OBSOLETE
NDA 088688 (pdf not found) INN (PHENYLPROPANOLAMINE HYDROCHLORIDE) BROMANATE (ALPHARMA US PHARMS) APPROVAL= AP YEAR= 0 DISCONTINUED OBSOLETE
NDA 088940 (pdf not found) INN (PHENYLPROPANOLAMINE HYDROCHLORIDE) CHLORPHENIRAMINE MALEATE AND PHENYLPROPANOLAMINE HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 0 DISCONTINUED OBSOLETE
NDA 011694 (pdf not found) INN (PHENYLPROPANOLAMINE HYDROCHLORIDE) DIMETANE-DC (ROBINS AH) APPROVAL= AP YEAR= 1958 DISCONTINUED OBSOLETE
NDA 012152 (pdf not found) INN (PHENYLPROPANOLAMINE HYDROCHLORIDE) ORNADE (GLAXOSMITHKLINE) APPROVAL= AP YEAR= 1959 DISCONTINUED OBSOLETE
NDA 012436 (pdf not found) INN (PHENYLPROPANOLAMINE HYDROCHLORIDE) DIMETAPP (WYETH CONS) APPROVAL= AP YEAR= 1960 DISCONTINUED OBSOLETE
NDA 013087 (pdf not found) INN (PHENYLPROPANOLAMINE HYDROCHLORIDE) DIMETAPP (WYETH CONS) APPROVAL= AP YEAR= 1962 DISCONTINUED OBSOLETE
NDA 018099 (pdf not found) INN (PHENYLPROPANOLAMINE HYDROCHLORIDE) CONTAC 12 HOUR (GLAXOSMITHKLINE) APPROVAL= AP YEAR= 1980 DISCONTINUED OBSOLETE
NDA 018298 (pdf not found) INN (PHENYLPROPANOLAMINE HYDROCHLORIDE) TAVIST-D (NOVARTIS) APPROVAL= AP YEAR= 1982 DISCONTINUED OBSOLETE
NDA 018050 (pdf not found) INN (CHLORPHENIRAMINE POLISTIREX ; PHENYLPROPANOLAMINE POLISTIREX) CORSYM (UCB INC) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 018556 (pdf not found) INN (PHENYLPROPANOLAMINE HYDROCHLORIDE) DEMAZIN (SCHERING PLOUGH) APPROVAL= AP YEAR= 1984 DISCONTINUED OBSOLETE
NDA 018809 (pdf not found) INN (PHENYLPROPANOLAMINE HYDROCHLORIDE) PHENYLPROPANOLAMINE HYDROCHLORIDE W/ CHLORPHENIRAMINE MALEATE (CENT PHARMS) APPROVAL= AP YEAR= 1984 DISCONTINUED OBSOLETE
NDA 018793 (pdf not found) INN (CHLORPHENIRAMINE MALEATE ; PHENYLPROPANOLAMINE HYDROCHLORIDE) COLD CAPSULE IV (GRAHAM DM) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 018794 (pdf not found) INN (CHLORPHENIRAMINE MALEATE ; PHENYLPROPANOLAMINE HYDROCHLORIDE) COLD CAPSULE V (GRAHAM DM) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 088723 (pdf not found) INN (PHENYLPROPANOLAMINE HYDROCHLORIDE) BROMANATE DC (ALPHARMA US PHARMS) APPROVAL= AP YEAR= 1985 DISCONTINUED OBSOLETE
NDA 088904 (pdf not found) INN (PHENYLPROPANOLAMINE HYDROCHLORIDE) MYPHETANE DC (WOCKHARDT) APPROVAL= AP YEAR= 1985 DISCONTINUED OBSOLETE
NDA 019613 (pdf not found) INN (PHENYLPROPANOLAMINE HYDROCHLORIDE) CONTAC (NOVARTIS) APPROVAL= AP YEAR= 1986 DISCONTINUED OBSOLETE
NDA 088359 (pdf not found) INN (PHENYLPROPANOLAMINE HYDROCHLORIDE) DRIZE (ASCHER) APPROVAL= AP YEAR= 1986 DISCONTINUED OBSOLETE
NDA 019410 (pdf not found) INN (PHENYLPROPANOLAMINE HYDROCHLORIDE) HYCOMINE (ENDO PHARMS) APPROVAL= AP YEAR= 1990 DISCONTINUED OBSOLETE
NDA 019411 (pdf not found) INN (PHENYLPROPANOLAMINE HYDROCHLORIDE) HYCOMINE PEDIATRIC (ENDO PHARMS) APPROVAL= AP YEAR= 1990 DISCONTINUED OBSOLETE
NDA 020640 (pdf not found) INN (PHENYLPROPANOLAMINE HYDROCHLORIDE) TAVIST-D (NOVARTIS) APPROVAL= AP YEAR= 1996 DISCONTINUED OBSOLETE
NDA 075103 (pdf not found) INN (HYDROCODONE BITARTRATE ; PHENYLPROPANOLAMINE HYDROCHLORIDE) CODAMINE (ALPHARMA US PHARMS) APPROVAL= AP YEAR= 2000 DISCONTINUED