e-Drug3D

244

DEXAMETHASONE PHOSPHATE


INN
DEXAMETHASONE PHOSPHATE

(has an active metabolite)

cas 312-93-6
CLASS

GLUCOCORTICOID
ANTIINFLAMMATORY

ROUTE (list)

OPHTHALMIC TOPICAL OTIC INJECTION INHALATION NASAL

ATC code

A01AC02
C05AA09
D07AB19
D07XB05
D10AA03
H02AB02
R01AD03
S01BA01
S01CB01
S02BA06
S03BA01
D07CB04
S01CA01
S02CA06
S03CA01
R01AD53

PK parameters

Target

TARGET GLUCOCORTICOID RECEPTOR

PDB
3TC5 (SELECTIVE TARGETING OF DISEASE-RELEVANT PROTEIN BINDING DOMAINS BY O-PHOSPHORYLATED NATURAL PRODUCT DERIVATIVES)

Ligand code = 3T5 (link to the list of PDB complexes)

Download experimental 3D coordinates of 3T5 with added hydrogens

DrugCentral

Glucocorticoid receptor UNIPROT P04150 NR3C1

Download SDF file Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, (11.beta.,16.alpha.)-

Formula:
C22H30FO8P

Calculated chemical properties:

MW 470.41
NB_atoms 32
XLogP 0.75
PSA 128.682
NB_HD 2
NB_HA 8
fsp3 0.73
Lipinski(0=no;1=yes) 1

FDA
NDA 062539 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE ; NEOMYCIN SULFATE) NEOMYCIN SULFATE-DEXAMETHASONE SODIUM PHOSPHATE (PHARMAFAIR) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 083702 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 084342 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXACEN-4 (CENT PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 084355 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 084493 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (EPIC PHARMA LLC) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 085606 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 085641 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (WYETH AYERST) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088071 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAIR (PHARMAFAIR) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088433 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAIR (PHARMAFAIR) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088448 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE (ABRAXIS PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088522 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (INTL MEDICATION) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089280 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089281 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089282 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089372 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 011977 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DECADRON (MERCK) APPROVAL= AP YEAR= 1959 DISCONTINUED
NDA 011983 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DECADRON (MERCK) APPROVAL= AP YEAR= 1959 DISCONTINUED
NDA 011984 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DECADRON (MERCK) APPROVAL= AP YEAR= 1959 DISCONTINUED
NDA 012071 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DECADRON (MERCK) APPROVAL= AP YEAR= 1959 DISCONTINUED
NDA 013334 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE ; LIDOCAINE HYDROCHLORIDE) DECADRON W/ XYLOCAINE (MERCK) APPROVAL= AP YEAR= 1962 DISCONTINUED
NDA 013413 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXACORT (UCB INC) APPROVAL= AP YEAR= 1962 DISCONTINUED
NDA 014694 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) HEXADROL (ASPEN GLOBAL INC) APPROVAL= AP YEAR= 1964 DISCONTINUED
NDA 014242 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXACORT (UCB INC) APPROVAL= AP YEAR= 1965 DISCONTINUED
NDA 050322 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE ; NEOMYCIN SULFATE) NEODECADRON (MERCK) APPROVAL= AP YEAR= 1969 DISCONTINUED
NDA 050324 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE ; NEOMYCIN SULFATE) NEODECADRON (MERCK) APPROVAL= AP YEAR= 1969 DISCONTINUED
NDA 083342 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) MAXIDEX (ALCON) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 084170 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (SOLA BARNES HIND) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 084173 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (SOLA BARNES HIND) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 084282 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (HIKMA) APPROVAL= AP YEAR= 1975
NDA 084855 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 084916 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1977
NDA 083161 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (DELL LABS) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 084752 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (BEL MAR) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 087065 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (LYPHOMED) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 087440 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (LUITPOLD) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 087668 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (WATSON LABS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 087702 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (HIKMA) APPROVAL= AP YEAR= 1982
NDA 088469 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088771 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (SANDOZ) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 062714 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE ; NEOMYCIN SULFATE) NEOMYCIN SULFATE-DEXAMETHASONE SODIUM PHOSPHATE (ALCON PHARMS LTD) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 089169 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (DR REDDYS) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 081125 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (TEVA PARENTERAL) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 081126 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (TEVA PARENTERAL) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 064055 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE ; NEOMYCIN SULFATE) NEOMYCIN SULFATE AND DEXAMETHASONE SODIUM PHOSPHATE (BAUSCH AND LOMB) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 040069 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (BAUSCH AND LOMB) APPROVAL= AP YEAR= 1996
NDA 040491 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE PRESERVATIVE FREE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2003
NDA 040572 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2005
NDA 040802 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (MYLAN LABS LTD) APPROVAL= AP YEAR= 2008
NDA 040803 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (MYLAN LABS LTD) APPROVAL= AP YEAR= 2008
NDA 203129 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2015
NDA 206781 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (EUGIA PHARMA) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 207442 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE PRESERVATIVE FREE (SOMERSET THERAPS LLC) APPROVAL= AP YEAR= 2018
NDA 207521 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (SOMERSET) APPROVAL= AP YEAR= 2018
NDA 208689 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (AMNEAL) APPROVAL= AP YEAR= 2018
NDA 208690 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE PRESERVATIVE FREE (AMNEAL) APPROVAL= AP YEAR= 2018
NDA 209192 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2018
NDA 210967 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (EUGIA PHARMA) APPROVAL= AP YEAR= 2019
NDA 211036 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (SOMERSET THERAPS LLC) APPROVAL= AP YEAR= 2019
NDA 210966 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (EUGIA PHARMA) APPROVAL= AP YEAR= 2020
NDA 215654 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (GLAND) APPROVAL= AP YEAR= 2021
NDA 211451 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (HIKMA) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 214890 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (GENEYORK PHARMS) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 214891 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (GENEYORK PHARMS) APPROVAL= AP YEAR= 2023 DISCONTINUED OBSOLETE
NDA 217797 (pdf not found) INN (DEXAMETHASONE SODIUM PHOSPHATE) DEXAMETHASONE SODIUM PHOSPHATE (MICRO LABS) APPROVAL= AP YEAR= 2024

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL