e-Drug3D

235

DICHLORPHENAMIDE

INN
DICHLORPHENAMIDE

cas 120-97-8

CLASS

SENSORY
ANTIGLAUCOMIC AGENTS
CARBONIC ANHYDRASE INHIBITORS
OPHTHALMICS

ROUTE (list)

ORAL

ATC code

S01EC02

PK parameters

Target

TARGET CARBONIC ANHYDRASE

PDB
2POU (THE CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 4,5-DICHLORO-BENZENE-1,3-DISULFONAMIDE)

Ligand code = I7A (link to the list of PDB complexes)

Download experimental 3D coordinates of I7A with added hydrogens

DrugCentral

Carbonic anhydrase 2 UNIPROT P00918 CA2

Carbonic anhydrase 1 UNIPROT P00915 CA1

Download SDF file

4,5-dichlorobenzene-1,3-disulfonamide

Formula:
C6H6Cl2N2O4S2

Calculated chemical properties:

MW 305.17
NB_atoms 16
XLogP 0.29
PSA 118.269
NB_HD 4
NB_HA 6
fsp3 0.00
Lipinski(0=no;1=yes) 1

FDA
NDA 011366 (label) INN (DICHLORPHENAMIDE) DARANIDE (XERIS) APPROVAL= AP YEAR= 1958 NEWMOLECULARENTITY
NDA 215924 (pdf not found) INN (DICHLORPHENAMIDE) ORMALVI (TORRENT) APPROVAL= AP YEAR= 2022