e-Drug3D
221
CHLOROTHIAZIDE
INN
CHLOROTHIAZIDE
cas 58-94-6
CLASS
CARDIOVASCULAR
DIURETIC
ANTIHYPERTENSIVE
MAY INVOLVE CARBONIC ANHYDRASE INHIBITION (PMID24352504)
ROUTE (list)
ORAL INJECTION
PK parameters
t1/2 2 HOUR
Solubility
VERY SLIGHTLY SOLUBLE IN WATER
TARGET CARBONIC ANHYDRASE
Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3
Formula:
C7H6ClN3O4S2
Calculated chemical properties:
MW 295.74
NB_atoms 17
XLogP 0.13
PSA 117.16
NB_HD 3
NB_HA 7
fsp3 0.00
Lipinski(0=no;1=yes) 1
NB_atoms 17
XLogP 0.13
PSA 117.16
NB_HD 3
NB_HA 7
fsp3 0.00
Lipinski(0=no;1=yes) 1
FDA
NDA 070654 (pdf not found) INN (CHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND CHLOROTHIAZIDE (PAR PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070783 (pdf not found) INN (CHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND CHLOROTHIAZIDE (PAR PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 084026 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 085165 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 086796 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088151 (pdf not found) INN (CHLOROTHIAZIDE ; RESERPINE) CHLOROTHIAZIDE W/ RESERPINE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 011145 (pdf not found) INN (CHLOROTHIAZIDE) DIURIL (RISING) APPROVAL= AP YEAR= 1958 DISCONTINUED
NDA 011635 (pdf not found) INN (CHLOROTHIAZIDE ; RESERPINE) DIUPRES-250 (MERCK) APPROVAL= AP YEAR= 1958 DISCONTINUED
NDA 011870 (label) INN (CHLOROTHIAZIDE) DIURIL (SALIX PHARMS) APPROVAL= AP YEAR= 1961
NDA 016016 (pdf not found) INN (CHLOROTHIAZIDE ; METHYLDOPA) ALDOCLOR-150 (MERCK) APPROVAL= AP YEAR= 1968 DISCONTINUED
NDA 084217 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 084388 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (MYLAN) APPROVAL= AP YEAR= 1975 OBSOLETE
NDA 085173 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (WATSON LABS) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 085569 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (ABC HOLDING) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 085485 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (SANDOZ) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 086028 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (HIKMA INTL PHARMS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 086938 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (LEDERLE) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 086940 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (LEDERLE) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 087736 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (HIKMA INTL PHARMS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 087744 (pdf not found) INN (CHLOROTHIAZIDE ; RESERPINE) CHLOROTHIAZIDE-RESERPINE (MYLAN) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 087745 (pdf not found) INN (CHLOROTHIAZIDE ; RESERPINE) CHLOROTHIAZIDE-RESERPINE (MYLAN) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 084853 (pdf not found) INN (CHLOROTHIAZIDE ; RESERPINE) CHLOROTHIAZIDE W/ RESERPINE (WATSON LABS) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 086795 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (WATSON LABS) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088365 (pdf not found) INN (CHLOROTHIAZIDE ; RESERPINE) CHLOROTHIAZIDE AND RESERPINE (HIKMA) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088557 (pdf not found) INN (CHLOROTHIAZIDE ; RESERPINE) CHLOROTHIAZIDE AND RESERPINE (HIKMA) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 090896 (pdf not found) INN (CHLOROTHIAZIDE SODIUM) CHLOROTHIAZIDE SODIUM (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2009
NDA 091546 (pdf not found) INN (CHLOROTHIAZIDE SODIUM) CHLOROTHIAZIDE SODIUM (SUN PHARM) APPROVAL= AP YEAR= 2011
NDA 202561 (pdf not found) INN (CHLOROTHIAZIDE SODIUM) CHLOROTHIAZIDE SODIUM (AM REGENT) APPROVAL= AP YEAR= 2013
NDA 202493 (pdf not found) INN (CHLOROTHIAZIDE SODIUM) CHLOROTHIAZIDE SODIUM (RK PHARMA) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 202462 (pdf not found) INN (CHLOROTHIAZIDE SODIUM) CHLOROTHIAZIDE SODIUM (SAGENT PHARMS INC) APPROVAL= AP YEAR= 2015
NDA 218630 (pdf not found) INN (CHLOROTHIAZIDE SODIUM) CHLOROTHIAZIDE SODIUM (GLAND) APPROVAL= AP YEAR= 2024
NDA 070654 (pdf not found) INN (CHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND CHLOROTHIAZIDE (PAR PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 070783 (pdf not found) INN (CHLOROTHIAZIDE ; METHYLDOPA) METHYLDOPA AND CHLOROTHIAZIDE (PAR PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 084026 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 085165 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 086796 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088151 (pdf not found) INN (CHLOROTHIAZIDE ; RESERPINE) CHLOROTHIAZIDE W/ RESERPINE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 011145 (pdf not found) INN (CHLOROTHIAZIDE) DIURIL (RISING) APPROVAL= AP YEAR= 1958 DISCONTINUED
NDA 011635 (pdf not found) INN (CHLOROTHIAZIDE ; RESERPINE) DIUPRES-250 (MERCK) APPROVAL= AP YEAR= 1958 DISCONTINUED
NDA 011870 (label) INN (CHLOROTHIAZIDE) DIURIL (SALIX PHARMS) APPROVAL= AP YEAR= 1961
NDA 016016 (pdf not found) INN (CHLOROTHIAZIDE ; METHYLDOPA) ALDOCLOR-150 (MERCK) APPROVAL= AP YEAR= 1968 DISCONTINUED
NDA 084217 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 084388 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (MYLAN) APPROVAL= AP YEAR= 1975 OBSOLETE
NDA 085173 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (WATSON LABS) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 085569 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (ABC HOLDING) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 085485 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (SANDOZ) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 086028 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (HIKMA INTL PHARMS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 086938 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (LEDERLE) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 086940 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (LEDERLE) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 087736 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (HIKMA INTL PHARMS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 087744 (pdf not found) INN (CHLOROTHIAZIDE ; RESERPINE) CHLOROTHIAZIDE-RESERPINE (MYLAN) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 087745 (pdf not found) INN (CHLOROTHIAZIDE ; RESERPINE) CHLOROTHIAZIDE-RESERPINE (MYLAN) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 084853 (pdf not found) INN (CHLOROTHIAZIDE ; RESERPINE) CHLOROTHIAZIDE W/ RESERPINE (WATSON LABS) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 086795 (pdf not found) INN (CHLOROTHIAZIDE) CHLOROTHIAZIDE (WATSON LABS) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088365 (pdf not found) INN (CHLOROTHIAZIDE ; RESERPINE) CHLOROTHIAZIDE AND RESERPINE (HIKMA) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088557 (pdf not found) INN (CHLOROTHIAZIDE ; RESERPINE) CHLOROTHIAZIDE AND RESERPINE (HIKMA) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 090896 (pdf not found) INN (CHLOROTHIAZIDE SODIUM) CHLOROTHIAZIDE SODIUM (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2009
NDA 091546 (pdf not found) INN (CHLOROTHIAZIDE SODIUM) CHLOROTHIAZIDE SODIUM (SUN PHARM) APPROVAL= AP YEAR= 2011
NDA 202561 (pdf not found) INN (CHLOROTHIAZIDE SODIUM) CHLOROTHIAZIDE SODIUM (AM REGENT) APPROVAL= AP YEAR= 2013
NDA 202493 (pdf not found) INN (CHLOROTHIAZIDE SODIUM) CHLOROTHIAZIDE SODIUM (RK PHARMA) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 202462 (pdf not found) INN (CHLOROTHIAZIDE SODIUM) CHLOROTHIAZIDE SODIUM (SAGENT PHARMS INC) APPROVAL= AP YEAR= 2015
NDA 218630 (pdf not found) INN (CHLOROTHIAZIDE SODIUM) CHLOROTHIAZIDE SODIUM (GLAND) APPROVAL= AP YEAR= 2024