e-Drug3D

2162

DORDAVIPRONE

INN
DORDAVIPRONE

cas 1616632-77-9

CLASS

ANTINEOPLASTIC
PROTEASE ACTIVATOR
TREATMENT OF PATIENTS WITH DIFFUSE MIDLINE GLIOMA

ROUTE (list)

ORAL

ATC code

PK parameters

Tmax 1.4 HOUR
VD 450 LITER
Cl 27 LITER / HOUR
PPB 96 PERCENT
t1/2 11 HOUR

Solubility

FREELY SOLUBLE IN WATER

Target

TARGET MITOCHONDRIAL CASEINOLYTIC PROTEASE P (CLPP)
DOPAMINE D2 RECEPTOR

Download SDF file

Imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, 2,4,6,7,8,9-hexahydro-4-[(2-methylphenyl)methyl]-7-(phenylmethyl)- (ACI)

Formula:
C24H26N4O

Calculated chemical properties:

MW 386.49
NB_atoms 29
XLogP 3.17
PSA 36.654
NB_HD 0
NB_HA 5
fsp3 0.33
Lipinski(0=no;1=yes) 1

FDA
NDA 219876 (pdf not found) INN (DORDAVIPRONE HYDROCHLORIDE) MODEYSO (CHIMERIX) APPROVAL= AP YEAR= 2025 NEWMOLECULARENTITY