e-Drug3D

2160

TALETRECTINIB

INN
TALETRECTINIB

cas 1505514-27-1

CLASS

ANTINEOPLASTIC
TREATMENT OF NON-SMALL CELL LUNG CANCER (NSCLC)
KINASE INHIBITOR

ROUTE (list)

ORAL

ATC code

PK parameters

Tmax 4 HOUR
VD 9820 LITER
Cl 63 LITER / HOUR
PPB 96 PERCENT
t1/2 66 HOUR

Solubility

PRACTICALLY INSOLUBLE IN WATER

Target

TARGET TYROSINE KINASE ROS1
TRKA
TRKB
TRKC

Download SDF file

Imidazo[1,2-b]pyridazin-6-amine, 3-[4-[(2R)-2-aminopropoxy]phenyl]-N-[(1R)-1-(3-fluorophenyl)ethyl]- (ACI)

Formula:
C23H24FN5O

Calculated chemical properties:

MW 405.47
NB_atoms 30
XLogP 4.43
PSA 70.65
NB_HD 3
NB_HA 6
fsp3 0.22
Lipinski(0=no;1=yes) 1

FDA
NDA 219713 (pdf not found) INN (TALETRECTINIB) IBTROZI (NUVATION) APPROVAL= AP YEAR= 2025 NEWMOLECULARENTITY