e-Drug3D

2156

SEBETRALSTAT

INN
SEBETRALSTAT

cas 1933514-13-6

CLASS

BLOOD
PLASMA KALLIKREIN INHIBITOR
TREATMENT OF ACUTE ATTACKS OF HEREDITARY ANGIOEDEMA (HAE)

ROUTE (list)

ORAL

ATC code

B06AC08

PK parameters

Tmax 1 HOUR
VD 70.1 LITER
Cl 30.7 LITER / HOUR
PPB 77 PERCENT
t1/2 7.1 HOUR

Solubility

PRACTICALLY INSOLUBLE IN WATER

Target

TARGET KALLIKREIN

Download SDF file

1H-Pyrazole-4-carboxamide, N-[(3-fluoro-4-methoxy-2-pyridinyl)methyl]-3-(methoxymethyl)-1-[[4-[(2-oxo-1(2H)-pyridinyl)methyl]phenyl]methyl]- (ACI)

Formula:
C26H26FN5O4

Calculated chemical properties:

MW 491.52
NB_atoms 36
XLogP 2.76
PSA 94.369
NB_HD 1
NB_HA 9
fsp3 0.23
Lipinski(0=no;1=yes) 1

FDA
NDA 219301 (label) INN (SEBETRALSTAT) EKTERLY (KALVISTA) APPROVAL= AP YEAR= 2025 NEWMOLECULARENTITY