e-Drug3D

2152

ZONGERTINIB

INN
ZONGERTINIB

cas 2728667-27-2

CLASS

ANTINEOPLASTIC
EPIDERMAL GROWTH FACTOR RECEPTOR 2 (HER2) KINASE INHIBITOR
TREATMENT OF NON-SQUAMOUS NON-SMALL CELL LUNG CANCER (NSCLC)

ROUTE (list)

ORAL

ATC code

PK parameters

F 76 PERCENT
Tmax 2 HOUR
VD 118 LITER
Cl 6.9 LITER / HOUR
PPB 99 PERCENT
t1/2 12 HOUR

Solubility

PRACTICALLY INSOLUBLE AT PH 6.8

Target

TARGET EPIDERMAL GROWTH FACTOR RECEPTOR 2 (HER2)

Download SDF file

2-Propenamide, N-[1-[8-[[3-methyl-4-[(1-methyl-1H-benzimidazol-5-yl)oxy]phenyl]amino]pyrimido[5,4-d]pyrimidin-2-yl]-4-piperidinyl]- (ACI)

Formula:
C29H29N9O2

Calculated chemical properties:

MW 535.61
NB_atoms 40
XLogP 4.42
PSA 106.949
NB_HD 2
NB_HA 11
fsp3 0.24
Lipinski(0=no;1=yes) 0

FDA
NDA 219042 (pdf not found) INN (ZONGERTINIB) HERNEXEOS (BOEHRINGER INGELHEIM) APPROVAL= AP YEAR= 2025 NEWMOLECULARENTITY