e-Drug3D

2145

BRENSOCATIB

INN
BRENSOCATIB

cas 1802148-05-5

CLASS

RESPIRATORY
DIPEPTIDYL PEPTIDASE 1 (DPP1) INHIBITOR
TREATMENT OF NON-CYSTIC FIBROSIS BRONCHIECTASIS

ROUTE (list)

ORAL

ATC code

PK parameters

F 80 PERCENT
Tmax 1.2 HOUR
VD 132 LITER
Cl 8.5 LITER / HOUR
PPB 87.2 PERCENT
t1/2 32 HOUR

Solubility

VERY SLIGHTLY SOLUBLE AT PH 6.8 IN WATER

Target

TARGET DIPEPTIDYL PEPTIDASE 1 (DPP1)

Download SDF file

1,4-Oxazepine-2-carboxamide, N-[(1S)-1-cyano-2-[4-(2,3-dihydro-3-methyl-2-oxo-5-benzoxazolyl)phenyl]ethyl]hexahydro-, (2S)- (ACI)

Formula:
C23H24N4O4

Calculated chemical properties:

MW 420.46
NB_atoms 31
XLogP 1.73
PSA 100.891
NB_HD 2
NB_HA 8
fsp3 0.35
Lipinski(0=no;1=yes) 1

FDA
NDA 217673 (label) INN (BRENSOCATIB) BRINSUPRI (INSMED INC) APPROVAL= AP YEAR= 2025 NEWMOLECULARENTITY