e-Drug3D

2135

SEPIAPTERIN

INN
SEPIAPTERIN

cas 17094-01-8

CLASS

METABOLISM
PHENYLALANINE HYDROXYLASE (PAH) ACTIVATOR
TREATMENT OF HYPERPHENYLALANINEMIA (HPA)
PRECURSOR OF THE ENZYMATIC CO-FACTOR TETRAHYDROBIOPTERIN (BH4) WHICH ACTIVATES PAH

ROUTE (list)

ORAL

ATC code

PK parameters

Tmax 2 HOUR
PPB 15.4 PERCENT

Solubility

SLIGHTLY SOLUBLE IN WATER 1.4 MILLIGRAM PER MILLILITER

Target

TARGET SEPIAPTERIN REDUCTASE
CARBONYL REDUCTASE
DHFR

DrugCentral

Download SDF file

4(3H)-Pteridinone, 2-amino-7,8-dihydro-6-[(2S)-2-hydroxy-1-oxopropyl]-

Formula:
C9H11N5O3

Calculated chemical properties:

MW 237.23
NB_atoms 17
XLogP -1.20
PSA 126.163
NB_HD 5
NB_HA 8
fsp3 0.33
Lipinski(0=no;1=yes) 1

FDA
NDA 219666 (label) INN (SEPIAPTERIN) SEPHIENCE (PTC THERAP) APPROVAL= AP YEAR= 2025 NEWMOLECULARENTITY