e-Drug3D

2124

ACOLTREMON

INN
ACOLTREMON

cas 68489-09-8

CLASS

SENSORY
TRPM8 THERMORECEPTOR AGONIST
TREATMENT OF THE SIGNS AND SYMPTOMS OF DRY EYE DISEASE

ROUTE (list)

OPHTHALMIC

ATC code

PK parameters

Solubility

INSOLUBLE IN WATER

Target

TARGET TRANSIENT RECEPTOR POTENTIAL MELASTATIN 8 (TRPM8)

PDB
6NR2 (CRYO-EM STRUCTURE OF THE TRPM8 ION CHANNEL IN COMPLEX WITH THE MENTHOL ANALOG WS-12 AND PI(4,5)P2)

Download experimental 3D coordinates of KXS with added hydrogens

Download SDF file

(1R,2S,5R)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide

Formula:
C18H27NO2

Calculated chemical properties:

MW 289.41
NB_atoms 21
XLogP 4.34
PSA 37.082
NB_HD 1
NB_HA 3
fsp3 0.61
Lipinski(0=no;1=yes) 1

FDA
NDA 217370 (pdf not found) INN (ACOLTREMON) TRYPTYR (ALCON LABS INC) APPROVAL= AP YEAR= 2025 NEWMOLECULARENTITY