e-Drug3D

2119

M AZACITIDINE

INN
AZACITIDINE

cas 2226-74-6

CLASS

ANTINEOPLASTIC
ANTIMETABOLITES
FAB MYELODYSPLASTIC SYNDROME
CYTOTOXIC
NUCLEOSIDE ANALOG OF CYTIDINE
HYPOMETHYLATION OF DNA AND RNA AFTER PHOSPHORYLATION BY KINASE UCK2

ROUTE (list)

ATC code

L01BC07

PK parameters

Target

TARGET DNA
DNA (CYTOSINE-5)-METHYLTRANSFERASE 1 DNMT1

DrugCentral

DNA (cytosine-5)-methyltransferase 1 UNIPROT P26358 DNMT1

DNA (cytosine-5)-methyltransferase 3A UNIPROT Q9Y6K1 DNMT3A

Download SDF file

1,3,5-Triazin-2(1H)-one, 4-amino-1-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-beta-D-ribofuranosyl]- (9CI, ACI)

Formula:
C8H15N4O14P3

Calculated chemical properties:

MW 480.12
NB_atoms 29
XLogP -5.34
PSA 269.342
NB_HD 4
NB_HA 18
fsp3 0.62
Lipinski(0=no;1=yes) 0

FDA
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