e-Drug3D

2107

GIVINOSTAT

INN
GIVINOSTAT

cas 497833-27-9

CLASS

MUSCULO-SKELETAL SYSTEM
HISTONE DEACETYLASE INHIBITOR
TREATMENT OF OF DUCHENNE MUSCULAR DYSTROPHY (DMD)

ROUTE (list)

ORAL

ATC code

M09AX14

PK parameters

Tmax 2.5 HOUR
PPB 96 PERCENT
t1/2 6 HOUR

Solubility

SLIGHTLY SOLUBLE IN WATER

Target

TARGET HISTONE DEACETYLASE

PDB
6UOC (CRYSTAL STRUCTURE OF DANIO RERIO HISTONE DEACETYLASE 6 CATALYTIC DOMAIN 1 (CD1) K330L MUTANT COMPLEXED WITH GIVINOSTAT)

Download experimental 3D coordinates of QCM with added hydrogens

Download SDF file

Carbamic acid, N-[4-[(hydroxyamino)carbonyl]phenyl]-, [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester (ACI)

Formula:
C24H27N3O4

Calculated chemical properties:

MW 421.49
NB_atoms 31
XLogP 4.55
PSA 94.47
NB_HD 3
NB_HA 7
fsp3 0.25
Lipinski(0=no;1=yes) 1

FDA
NDA 217865 (label) INN (GIVINOSTAT HYDROCHLORIDE) DUVYZAT (ITALFARMACO SPA) APPROVAL= AP YEAR= 2024 NEWMOLECULARENTITY