e-Drug3D

2106

RESMETIROM

INN
RESMETIROM

cas 920509-32-6

CLASS

HORMONES
THYROID HORMONE RECEPTOR-BETA (THR-BETA) AGONIST
TREATMENT OF NONCIRRHOTIC NONALCOHOLIC STEATOHEPATITIS (NASH)

ROUTE (list)

ORAL

ATC code

PK parameters

Tmax 4 HOUR
VD 68 LITER
Cl 17.5 LITER / HOUR
PPB 99 PERCENT
t1/2 4.5 HOUR

Solubility

0.44 MILLIGRAM PER MILLILITER AT PH 7.04

Target

TARGET THYROID HORMONE RECEPTOR BETA

Download SDF file

1,2,4-Triazine-6-carbonitrile, 2-[3,5-dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo- (ACI)

Formula:
C17H12Cl2N6O4

Calculated chemical properties:

MW 435.23
NB_atoms 29
XLogP 2.10
PSA 126.973
NB_HD 2
NB_HA 10
fsp3 0.18
Lipinski(0=no;1=yes) 1

FDA
NDA 217785 (label) INN (RESMETIROM) REZDIFFRA (MADRIGAL) APPROVAL= AP YEAR= 2024 NEWMOLECULARENTITY