e-Drug3D

2103

LOTILANER

INN
LOTILANER

cas 1369852-71-0

CLASS

ANTIPARASITIC
TREATMENT OF DEMODEX BLEPHARITIS
GAMMA-AMINOBUTYRIC ACID (GABA)-GATED CHLORIDE CHANNEL INHIBITOR SELECTIVE FOR MITES (NOT AN INHIBITOR OF MAMMALIAN GABA)

ROUTE (list)

OPHTHALMIC

ATC code

S01AX25

PK parameters

Tmax 2 HOUR
PPB 99.9 PERCENT
t1/2 264 HOUR

Target

TARGET GAMMA-AMINOBUTYRIC ACID (GABA)-GATED CHLORIDE CHANNEL

DrugCentral

Gaba-gated chloride channel, putative UNIPROT E0V9W2 8233868

Download SDF file

2-Thiophenecarboxamide, 5-[(5S)-4,5-dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl]-3-methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]- (ACI)

Formula:
C20H14Cl3F6N3O3S

Calculated chemical properties:

MW 596.76
NB_atoms 36
XLogP 6.01
PSA 79.122
NB_HD 2
NB_HA 6
fsp3 0.35
Lipinski(0=no;1=yes) 0

FDA
NDA 217603 (label) INN (LOTILANER) XDEMVY (TARSUS) APPROVAL= AP YEAR= 2023 NEWMOLECULARENTITY