e-Drug3D

2101

ZURANOLONE

INN
ZURANOLONE

cas 1632051-40-1

CLASS

NERVOUS SYSTEM
NEUROACTIVE STEROID GAMMA-AMINOBUTYRIC ACID (GABA) A RECEPTOR POSITIVE MODULATOR INDICATED FOR THE TREATMENT OF POSTPARTUM DEPRESSION (PPD)

ROUTE (list)

ORAL

ATC code

N06AX31

PK parameters

Tmax 5.5 HOUR
VD 500 LITER
Cl 33 LITER / HOUR
PPB 99.5 PERCENT
t1/2 22.15 HOUR

Solubility

PRACTICALLLY INSOLUBLE IN WATER

Target

TARGET GABA A RECEPTOR

DrugCentral

Gamma-aminobutyric acid receptor subunit alpha-1 UNIPROT P14867

Download SDF file

1H-Pyrazole-4-carbonitrile, 1-[(3alpha,5beta)-3-hydroxy-3-methyl-20-oxo-19-norpregnan-21-yl]- (ACI)

Formula:
C25H35N3O2

Calculated chemical properties:

MW 409.56
NB_atoms 30
XLogP 4.34
PSA 68.482
NB_HD 1
NB_HA 5
fsp3 0.80
Lipinski(0=no;1=yes) 1

FDA
NDA 217369 (pdf not found) INN (ZURANOLONE) ZURZUVAE (BIOGEN INC) APPROVAL= AP YEAR= 2024