e-Drug3D

2099

M QUIZARTINIB

INN
QUIZARTINIB

cas 1225542-12-0

CLASS

ANTINEOPLASTIC
TREATMENT OF ACUTE MYELOID LEUKEMIA (AML)
TYROSINE KINASE FLT3 INHIBITOR
BIND TO THE ADENOSINE TRIPHOSPHATE (ATP) BINDING DOMAIN

ROUTE (list)

ATC code

L01EX11

PK parameters

Tmax 5.5 HOUR
PPB 99 PERCENT
t1/2 136 HOUR

Target

TARGET TYROSINE KINASE FLT3

Receptor-type tyrosine-protein kinase FLT3 UNIPROT P36888 FLT3

Download SDF file

Urea, N-[5-(2-hydroxy-1,1-dimethylethyl)-3-isoxazolyl]-N-[4-[7-[2-(4-morpholinyl)ethoxy]imidazo[2,1-b]benzothiazol-2-yl]phenyl]- (ACI)

Formula:
C29H32N6O5S

Calculated chemical properties:

MW 576.68
NB_atoms 41
XLogP 4.83
PSA 120.023
NB_HD 3
NB_HA 11
fsp3 0.34
Lipinski(0=no;1=yes) 0

FDA
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