e-Drug3D

2093

ENMETAZOBACTAM

DISCONTINUED

INN
ENMETAZOBACTAM

cas 1001404-83-6

CLASS

ANTIINFECTIVES
BETA-LACTAMASE INHIBITOR
TREATMENT OF COMPLICATED URINARY TRACT INFECTIONS (CUTI) INCLUDING PYELONEPHRITIS

ROUTE (list)

INTRAVENOUS

ATC code

PK parameters

VD 25.26 LITER
Cl 7.6 LITER / HOUR
PPB NEGLIGIBLE
t1/2 2.6 HOUR

Target

TARGET BETA-LACTAMASE

PDB
6T35 (CRYSTAL STRUCTURE OF AMPC FROM E.COLI WITH ENMETAZOBACTAM (AAI-101))

Download experimental 3D coordinates of M9W with added hydrogens

Download SDF file

1H-1,2,3-Triazolium, 3-[[(2S,3S,5R)-2-carboxy-3-methyl-4,4-dioxido-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-3-yl]methyl]-1-methyl-

Formula:
C11H15N4O5S

Calculated chemical properties:

MW 314.33
NB_atoms 21
XLogP -3.43
PSA 109.919
NB_HD 0
NB_HA 8
fsp3 0.64
Lipinski(0=no;1=yes) 1

FDA
NDA 216165 (label) INN (CEFEPIME HYDROCHLORIDE ; ENMETAZOBACTAM) EXBLIFEP (ALLECRA THERAPS) APPROVAL= AP YEAR= 2024 DISCONTINUED