e-Drug3D

2091

VAMOROLONE

INN
VAMOROLONE

cas 13209-41-1

CLASS

HORMONES
TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY (DMD)
CORTICOSTEROID

ROUTE (list)

ORAL

ATC code

H02AB18

PK parameters

Tmax 2 HOUR
VD 162 LITER (BODY WEIGHT OF 20 KG)
Cl 58 LITER / HOUR (BODY WEIGHT OF 20 KG)
PPB 88.1 PERCENT
t1/2 2 HOUR

Target

TARGET GLUCOCORTICOID RECEPTOR

PDB
6W9M (STRUCTURE OF THE ANCESTRAL GLUCOCORTICOID RECEPTOR 2 LIGAND BINDING DOMAIN IN COMPLEX WITH VAMOROLONE AND SHP COREGULATOR FRAGMENT)

Download experimental 3D coordinates of TUV with added hydrogens

Download SDF file

Pregna-1,4,9(11)-triene-3,20-dione, 17,21-dihydroxy-16-methyl-, (16alpha)- (9CI, ACI)

Formula:
C22H28O4

Calculated chemical properties:

MW 356.44
NB_atoms 26
XLogP 2.75
PSA 70.736
NB_HD 2
NB_HA 4
fsp3 0.64
Lipinski(0=no;1=yes) 1

FDA
NDA 215239 (label) INN (VAMOROLONE) AGAMREE (CATALYST PHARMS) APPROVAL= AP YEAR= 2023 NEWMOLECULARENTITY