e-Drug3D

2080

REZAFUNGIN

INN
REZAFUNGIN

cas 1396640-59-7

CLASS

ANTIINFECTIVES
ECHINOCANDIN ANTIFUNGAL
TREATMENT OF CANDIDEMIA AND INVASIVE CANDIDIASIS
SEMISYNTHETIC LIPOPEPTIDE
INHIBITS THE SYNTHESIS OF 1,3-BETA-D-GLUCAN

ROUTE (list)

INTRAVENOUS

ATC code

J02AX08

PK parameters

VD 67 LITER
Cl 0.35 LITER / HOUR
PPB 97.1 PERCENT
t1/2 152 HOUR

Solubility

FREELY SOLUBLE IN WATER

Target

TARGET 1,3-BETA-D-GLUCAN SYNTHASE

DrugCentral

1,3-beta-glucan synthase UNIPROT O13428

Download SDF file

Echinocandin B, 1-[(4R,5R)-4-hydroxy-N2-[[4-(pentyloxy)[1,1:4,1-terphenyl]-4-yl]carbonyl]-5-[2-(trimethylammonio)ethoxy]-L-ornithine]-4-[(4S)-4-hydroxy-4-(4-hydroxyphenyl)-L-allothreonine]- (ACI)

Formula:
C63H85N8O17

Calculated chemical properties:

MW 1226.39
NB_atoms 88
XLogP -0.20
PSA 321.767
NB_HD 13
NB_HA 24
fsp3 0.51
Lipinski(0=no;1=yes) 0

FDA
NDA 217417 (pdf not found) INN (REZAFUNGIN ACETATE) REZZAYO (MUNDIPHARMA) APPROVAL= AP YEAR= 2023 NEWMOLECULARENTITY