e-Drug3D

2072

SPARSENTAN

INN
SPARSENTAN

cas 254740-64-2

CLASS

CARDIOVASCULAR
ENDOTHELIN TYPE A RECEPTOR (ETAR) (KI = 12.8 NANOMOLAR) AND ANGIOTENSIN II TYPE 1 RECEPTOR ANTAGONIST (KI = 0.36 NANOMOLAR)
REDUCE PROTEINURIA

ROUTE (list)

ORAL

ATC code

C09XX01

PK parameters

Tmax 3 HOUR
VD 61.4 LITER
Cl 3.88 LITER / HOUR
PPB 99 PERCENT
t1/2 9.6 HOUR

Solubility

PRACTICALLY INSOLUBLE IN WATER

Target

TARGET ANGIOTENSIN II TYPE 1 RECEPTOR (AT1R)
ENDOTHELIN TYPE A RECEPTOR (ETAR)

DrugCentral

Type-1 angiotensin II receptor UNIPROT P30556 AGTR1

Endothelin-1 receptor UNIPROT P25101 EDNRA

Download SDF file

[1,1-Biphenyl]-2-sulfonamide, 4-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(4,5-dimethyl-3-isoxazolyl)-2-(ethoxymethyl)- (9CI, ACI)

Formula:
C32H40N4O5S

Calculated chemical properties:

MW 592.75
NB_atoms 42
XLogP 6.54
PSA 104.795
NB_HD 1
NB_HA 9
fsp3 0.47
Lipinski(0=no;1=yes) 0

FDA
NDA 216403 (label) INN (SPARSENTAN) FILSPARI (TRAVERE) APPROVAL= AP YEAR= 2023 NEWMOLECULARENTITY