e-Drug3D

2071

ZAVEGEPANT

INN
ZAVEGEPANT

cas 1337918-83-8

CLASS

NERVOUS SYSTEM
CALCITONIN GENE-RELATED PEPTIDE RECEPTOR ANTAGONIST
TREATMENT OF MIGRAINE

ROUTE (list)

NASAL

ATC code

N02CD08

PK parameters

F 5 PERCENT
Tmax 0.5 HOUR
VD 1774 LITER
Cl 266 LITER / HOUR
PPB 90 PERCENT
t1/2 6.55 HOUR

Solubility

FREELY SOLUBLE IN WATER

Target

TARGET CALCITONIN GENE-RELATED PEPTIDE (CGRP) RECEPTOR

DrugCentral

Calcitonin gene-related peptide type 1 receptor UNIPROT Q16602 CALCRL

Download SDF file

1-Piperidinecarboxamide, 4-(1,2-dihydro-2-oxo-3-quinolinyl)-N-[(1R)-1-[(7-methyl-1H-indazol-5-yl)methyl]-2-[4-(1-methyl-4-piperidinyl)-1-piperazinyl]-2-oxoethyl]- (ACI)

Formula:
C36H46N8O3

Calculated chemical properties:

MW 638.81
NB_atoms 47
XLogP 3.45
PSA 109.389
NB_HD 3
NB_HA 11
fsp3 0.50
Lipinski(0=no;1=yes) 0

FDA
NDA 216386 (pdf not found) INN (ZAVEGEPANT HYDROCHLORIDE) ZAVZPRET (PFIZER) APPROVAL= AP YEAR= 2023 NEWMOLECULARENTITY