e-Drug3D

2066

PHENOBARBITAL

INN
PHENOBARBITAL

cas 50-06-6

CLASS

NERVOUS SYSTEM
BARBITURATE INDICATED FOR THE TREATMENT OF NEONATAL SEIZURES IN TERM AND PRETERM INFANTS
GABA MODULATOR

ROUTE (list)

INTRAVENOUS

ATC code

N03AA02

PK parameters

t1/2 168 HOUR

Solubility

SOLUBLE IN WATER

Target

TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT ALPHA-1 (GABAA)

PDB
6X3W (HUMAN GABAA RECEPTOR ALPHA1-BETA2-GAMMA2 SUBTYPE IN COMPLEX WITH GABA PLUS PHENOBARBITAL)

Download experimental 3D coordinates of UQA with added hydrogens

Gamma-aminobutyric acid receptor subunit alpha-1 UNIPROT P14867 GABRA1

Download SDF file

2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-phenyl- (9CI, ACI)

Formula:
C12H12N2O3

Calculated chemical properties:

MW 232.24
NB_atoms 17
XLogP 0.70
PSA 78.793
NB_HD 2
NB_HA 5
fsp3 0.25
Lipinski(0=no;1=yes) 1

FDA
NDA 215910 (label) INN (PHENOBARBITAL SODIUM) SEZABY (SUN PHARM INDS INC) APPROVAL= AP YEAR= 2022