e-Drug3D

2055

GANAXOLONE

INN
GANAXOLONE

cas 38398-32-2

CLASS

NERVOUS SYSTEM
NEUROACTIVE STEROID GAMMA-AMINOBUTYRIC ACID (GABA) A RECEPTOR POSITIVE MODULATOR
TREATMENT OF SEIZURES ASSOCIATED WITH CDKL5 DEFICIENCY DISORDER
ANALOG OF ENDOGENOUS NEUROSTEROID ALLOPREGNANOLONE

ROUTE (list)

ORAL

ATC code

N03AX27

PK parameters

Tmax 2.5 HOUR
PPB 99 PERCENT
t1/2 34 HOUR

Solubility

LOW AQUEOUS SOLUBILITY

Target

TARGET GABA A

DrugCentral

Gamma-aminobutyric acid receptor subunit alpha-1 UNIPROT P14867

Download SDF file

Pregnan-20-one, 3-hydroxy-3-methyl-, (3alpha,5alpha)- (9CI, ACI)

Formula:
C22H36O2

Calculated chemical properties:

MW 332.51
NB_atoms 24
XLogP 4.99
PSA 35.075
NB_HD 1
NB_HA 2
fsp3 0.95
Lipinski(0=no;1=yes) 1

FDA
NDA 215904 (pdf not found) INN (GANAXOLONE) ZTALMY (MARINUS) APPROVAL= AP YEAR= 2022 NEWMOLECULARENTITY