e-Drug3D

2052

ODEVIXIBAT

INN
ODEVIXIBAT

cas 501692-44-0

CLASS

METABOLISM
ILEAL BILE ACID TRANSPORTER INHIBITOR (IBAT)
TREATMENT OF PRURITUS IN PATIENTS WITH PFIC

ROUTE (list)

ORAL

ATC code

A05AX05

PK parameters

Tmax 3 HOUR
PPB 99 PERCENT
t1/2 2.3 HOUR

Solubility

INCREASES IN WATER WITH PH

Target

TARGET ILEAL BILE ACID TRANSPORTER

DrugCentral

Ileal sodium bile acid cotransporter UNIPROT Q12908 SLC10A2

Download SDF file

Butanoic acid, 2-[[(2R)-2-[[2-[[3,3-dibutyl-2,3,4,5-tetrahydro-7-(methylthio)-1,1-dioxido-5-phenyl-1,2,5-benzothiadiazepin-8-yl]oxy]acetyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-, (2S)

Formula:
C37H48N4O8S2

Calculated chemical properties:

MW 739.93
NB_atoms 51
XLogP 4.54
PSA 161.848
NB_HD 4
NB_HA 12
fsp3 0.43
Lipinski(0=no;1=yes) 0

FDA
NDA 215498 (label) INN (ODEVIXIBAT) BYLVAY (IPSEN) APPROVAL= AP YEAR= 2021 NEWMOLECULARENTITY