e-Drug3D

2043

VONOPRAZAN

INN
VONOPRAZAN

cas 881681-00-1

CLASS

METABOLISM
POTASSIUM-COMPETITIVE ACID BLOCKER (PCAB)
SUPPRESSES BASAL AND STIMULATED GASTRIC ACID SECRETION
ACID (PROTON) PUMP

ROUTE (list)

ORAL

ATC code

A02BC08
A02BD17
A02BD14
A02BD15

PK parameters

Tmax 2.5 HOUR
VD 1001 LITER
Cl 97.3 LITER / HOUR
PPB 86.5 PERCENT
t1/2 7.1 HOUR

Solubility

SLIGHTLY SOLUBLE IN WATER

Target

TARGET POTASSIUM-TRANSPORTING ATPASE

PDB
5YLU (CRYSTAL STRUCTURE OF THE GASTRIC PROTON PUMP COMPLEXED WITH VONOPRAZAN)

Ligand code = HKT (link to the list of PDB complexes)

Download experimental 3D coordinates of HKT with added hydrogens

DrugCentral

Potassium-transporting ATPase UNIPROT P20648 ATP4A

Download SDF file

1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)- (9CI, ACI)

Formula:
C17H16FN3O2S

Calculated chemical properties:

MW 345.40
NB_atoms 24
XLogP 2.65
PSA 57.8
NB_HD 1
NB_HA 5
fsp3 0.12
Lipinski(0=no;1=yes) 1

FDA
NDA 215152 (pdf not found) INN (AMOXICILLIN ; CLARITHROMYCIN ; VONOPRAZAN FUMARATE) VOQUEZNA TRIPLE PAK (PHATHOM) APPROVAL= AP YEAR= 2022
NDA 215153 (pdf not found) INN (AMOXICILLIN ; VONOPRAZAN FUMARATE) VOQUEZNA DUAL PAK (PHATHOM) APPROVAL= AP YEAR= 2022
NDA 215151 (pdf not found) INN (VONOPRAZAN FUMARATE) VOQUEZNA (PHATHOM) APPROVAL= AP YEAR= 2023 NEWAPPLICATION
NDA 218710 (pdf not found) INN (VONOPRAZAN FUMARATE) VOQUEZNA (PHATHOM PHARMACEUTICALS INC) APPROVAL= AP YEAR= 2024 NEWAPPLICATION