e-Drug3D

2024

REMDESIVIR

INN
REMDESIVIR

(has an active metabolite)

cas 1809249-37-3

CLASS

ANTIINFECTIVES
SARS-COV-2 NUCLEOTIDE ANALOG RNA POLYMERASE INHIBITOR
ANTIVIRAL

ROUTE (list)

INTRAVENOUS

ATC code

J05AB16

PK parameters

Tmax 0.67 HOUR
PPB 90.8 PERCENT
t1/2 1 HOUR

Target

TARGET RNA POLYMERASE

DrugCentral

Replicase polyprotein 1ab UNIPROT P0DTD1 REP

Download SDF file

L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 2-ethylbutyl ester, 6-ester with 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile

Formula:
C27H35N6O8P

Calculated chemical properties:

MW 602.58
NB_atoms 42
XLogP 2.31
PSA 193.969
NB_HD 5
NB_HA 14
fsp3 0.48
Lipinski(0=no;1=yes) 0

FDA
NDA 214787 (label) INN (REMDESIVIR) VEKLURY (GILEAD SCIENCES INC) APPROVAL= AP YEAR= 2020