e-Drug3D

2019

MELPHALAN FLUFENAMIDE

DISCONTINUED

INN
MELPHALAN FLUFENAMIDE

cas 380449-51-4

CLASS

ANTINEOPLASTIC
A PEPTIDE CONJUGATED ALKYLATING DRUG
TREATMENT OF REFRACTORY MULTIPLE MYELOMA
NITROGEN MUSTARD DRUG
PRODRUG

ROUTE (list)

INTRAVENOUS

ATC code

L01AA03
L01AA10

PK parameters

Tmax 0.5 HOUR
VD 35 LITER
Cl 692 LITER / HOUR
t1/2 0.035 HOUR

Solubility

SPARSELY SOLUBLE IN AQUEOUS SOLUTIONS

Target

TARGET DNA

DrugCentral

Unknown

Download SDF file

L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-L-phenylalanyl-4-fluoro-, ethyl ester

Formula:
C24H30Cl2FN3O3

Calculated chemical properties:

MW 498.41
NB_atoms 33
XLogP 3.27
PSA 80.073
NB_HD 3
NB_HA 6
fsp3 0.42
Lipinski(0=no;1=yes) 1

FDA
NDA 214383 (label) INN (MELPHALAN FLUFENAMIDE HYDROCHLORIDE) PEPAXTO (ONCOPEPTIDES AB) APPROVAL= AP YEAR= 2021 NEWMOLECULARENTITY DISCONTINUED OBSOLETE