e-Drug3D

2007

PONESIMOD

INN
PONESIMOD

cas 854107-55-4

CLASS

IMMUNOMODULATING
IMMUNOSUPPRESSANT
SPHINGOSINE1-PHOSPHATE (S1P) RECEPTOR 1 MODULATOR
TREATMENT OF RELAPSING FORMS OF MULTIPLE SCLEROSIS (MS)

ROUTE (list)

ORAL

ATC code

L04AE04

PK parameters

F 84 PERCENT
Tmax 3 HOUR
VD 160 LITER
Cl 3.8 LITER / HOUR
PPB 99 PERCENT
t1/2 33 HOUR

Solubility

PACTICALLY INSOLUBLE IN WATER

Target

TARGET SPHINGOSINE1-PHOSPHATE (S1P) RECEPTOR 1

Sphingosine 1-phosphate receptor 1 UNIPROT P21453 S1PR1

Download SDF file

4-Thiazolidinone, 5-[[3-chloro-4-[(2R)-2,3-dihydroxypropoxy]phenyl]methylene]-3-(2-methylphenyl)-2-(propylimino)-, (2Z,5Z)-

Formula:
C23H25ClN2O4S

Calculated chemical properties:

MW 460.97
NB_atoms 31
XLogP 4.27
PSA 78.113
NB_HD 2
NB_HA 6
fsp3 0.30
Lipinski(0=no;1=yes) 1

FDA
NDA 213498 (pdf not found) INN (PONESIMOD) PONVORY (VANDA PHARMS INC) APPROVAL= AP YEAR= 2021 NEWMOLECULARENTITY