e-Drug3D

1997

CABOTEGRAVIR

INN
CABOTEGRAVIR

cas 1051375-10-0

CLASS

ANTIINFECTIVES
(HIV-1) INTEGRASE STRAND TRANSFER INHIBITOR (INSTI)
ANTIRETROVIRAL DRUG

ROUTE (list)

ORAL INTRAMUSCULAR

ATC code

J05AJ04

PK parameters

Tmax 3 HOUR
PPB 99.8 PERCENT
t1/2 41 HOUR

Solubility

SLIGHTLY SOLUBLE IN WATER

Target

TARGET HIV-1 INTEGRASE

DrugCentral

Integrase UNIPROT Q7ZJM1 pol

Download SDF file

Oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide, N-[(2,4-difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-, (3S,11aR)-

Formula:
C19H17F2N3O5

Calculated chemical properties:

MW 405.36
NB_atoms 29
XLogP 0.96
PSA 92.103
NB_HD 2
NB_HA 8
fsp3 0.32
Lipinski(0=no;1=yes) 1

FDA
NDA 212887 (pdf not found) INN (CABOTEGRAVIR SODIUM) VOCABRIA (VIIV HLTHCARE) APPROVAL= AP YEAR= 2021
NDA 212888 (pdf not found) INN (CABOTEGRAVIR ; RILPIVIRINE) CABENUVA KIT (VIIV HLTHCARE) APPROVAL= AP YEAR= 2021
NDA 215499 (pdf not found) INN (CABOTEGRAVIR) APRETUDE (VIIV HLTHCARE) APPROVAL= AP YEAR= 2021