e-Drug3D

1992

SN38

INN
SN38
SACITUZUMAB GOVITECAN-HZIY

cas 86639-52-3

CLASS

ANTINEOPLASTIC
ANTIBODY-DRUG CONJUGATE (ADC)
A TOPOISOMERASE INHIBITOR
TREATMENT OF METASTATIC TRIPLE-NEGATIVE BREAST CANCER (MTNBC)

ROUTE (list)

INJECTION

ATC code

L01FX17

PK parameters

t1/2 18 HOUR

Target

TARGET TOPOISOMERASE

PDB
6VXJ (STRUCTURE OF ABCG2 BOUND TO SN38)

Download experimental 3D coordinates of RS4 with added hydrogens

DNA topoisomerase 1 UNIPROT P11387 TOP1

Tumor-associated calcium signal transducer 2 UNIPROT P09758 TACSTD2

Download SDF file

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (4S)-

Formula:
C22H20N2O5

Calculated chemical properties:

MW 392.40
NB_atoms 29
XLogP 2.35
PSA 98.099
NB_HD 2
NB_HA 7
fsp3 0.32
Lipinski(0=no;1=yes) 1

FDA
NDA 761115 (pdf not found) INN (SACITUZUMAB GOVITECAN-HZIY) TRODELVY (IMMUNOMEDICS INC) APPROVAL= AP YEAR= 2020 NEWMOLECULARENTITY