e-Drug3D

1989

M SELUMETINIB

INN
SELUMETINIB

cas 606143-88-8

CLASS

ANTINEOPLASTIC
TREATMENT OF PEDIATRIC NEUROFIBROMAS (PN)
MITOGEN-ACTIVATED PROTEIN KINASE KINASES 1 AND 2 INHIBITOR
N-DESMETHYL SELUMETINIB REPRESENTS LESS THAN 10% OF SELUMETINIB LEVELS IN HUMAN PLASMA BUT IS APPROXIMATELY 3 TO 5 TIMES MORE POTENT CONTRIBUTING TO ABOUT 21% TO 35% OF THE OVERALL PHARMACOLOGIC ACTIVITY

ROUTE (list)

ATC code

L01EE04

PK parameters

Target

TARGET MEK1
MEK2

DrugCentral

Dual specificity mitogen-activated protein kinase kinase 1 UNIPROT Q02750 MAP2K1

Dual specificity mitogen-activated protein kinase kinase 2 UNIPROT P36507 MAP2K2

Download SDF file

1H-Benzimidazole-5-carboxamide, 6-[(4-bromo-2-chlorophenyl)amino]-7-fluoro-N-(2-hydroxyethoxy)-

Formula:
C16H13BrClFN4O3

Calculated chemical properties:

MW 443.65
NB_atoms 26
XLogP 3.52
PSA 93.873
NB_HD 4
NB_HA 7
fsp3 0.12
Lipinski(0=no;1=yes) 1

FDA
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