e-Drug3D

1986

LURBINECTEDIN

INN
LURBINECTEDIN

cas 497871-47-3

CLASS

ANTINEOPLASTIC
TREATMENT OF METASTATIC SMALL CELL LUNG CANCER (SCLC)
COVALENT ALKYLATING DRUG
BINDS GUANINE RESIDUES IN THE MINOR GROOVE OF DNA FORMING ADDUCTS

ROUTE (list)

INTRAVENOUS

ATC code

L01XX69

PK parameters

VD 504 LITER
Cl 11 LITER / HOUR
PPB 99 PERCENT
t1/2 51 HOUR

Target

TARGET DNA

DrugCentral

Unknown

Download SDF file

Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'-[1H]pyrido[3,4-b]indol]-19-one, 5-(acetyloxy)-2',3',4',6,6a,7,9',13,14,16-decahydro-8,14-dihydroxy-6',9-dimethoxy-4,10,23-trimethyl-, (1'R,6R,6aR,7R,13S,14S,16R)- (9CI)

Formula:
C41H44N4O10S

Calculated chemical properties:

MW 784.87
NB_atoms 56
XLogP 4.19
PSA 165.713
NB_HD 4
NB_HA 14
fsp3 0.46
Lipinski(0=no;1=yes) 0

FDA
NDA 213702 (label) INN (LURBINECTEDIN) ZEPZELCA (JAZZ) APPROVAL= AP YEAR= 2020