e-Drug3D

1982

TUCATINIB

INN
TUCATINIB

cas 937263-43-9

CLASS

ANTINEOPLASTIC
A TYROSINE KINASE INHIBITOR OF HER2
TREATMENT OF BREAST CANCER

ROUTE (list)

ORAL

ATC code

L01EH03

PK parameters

Tmax 2 HOUR
VD 1670 LITER
Cl 148 LITER / HOUR
PPB 97.1 PERCENT
t1/2 8.5 HOUR

Target

TARGET HER2

ERBB2,ERBB3 UNIPROT P04626 ERBB2

Download SDF file

4,6-Quinazolinediamine, N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-

Formula:
C26H24N8O2

Calculated chemical properties:

MW 480.53
NB_atoms 36
XLogP 5.09
PSA 99.32
NB_HD 2
NB_HA 10
fsp3 0.19
Lipinski(0=no;1=yes) 0

FDA
NDA 213411 (label) INN (TUCATINIB) TUKYSA (SEAGEN) APPROVAL= AP YEAR= 2020 NEWMOLECULARENTITY