e-Drug3D

1972

OSILODROSTAT

INN
OSILODROSTAT

cas 928134-65-0

CLASS

HORMONES
CORTISOL SYNTHESIS INHIBITOR
TREATMENT OF CUSHING’S DISEASE
INHIBITOR OF 11 BETA-HYDROXYLASE (CYP11B1) (IC50 = 2.5 NM)

ROUTE (list)

ORAL

ATC code

H02CA02

PK parameters

Tmax 1 HOUR
VD 100 LITER
PPB 36.4 PERCENT
t1/2 4 HOUR

Target

TARGET 11 BETA-HYDROXYLASE (CYP11B1)

PDB
7M8V (HUMAN CYP11B2 IN COMPLEX WITH LCI699)

Download experimental 3D coordinates of YSY with added hydrogens

Cytochrome P450 11B1, mitochondrial UNIPROT P15538 CYP11B1

Download SDF file

Benzonitrile, 4-[(5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluoro-

Formula:
C13H10FN3

Calculated chemical properties:

MW 227.24
NB_atoms 17
XLogP 2.43
PSA 33.109
NB_HD 0
NB_HA 3
fsp3 0.23
Lipinski(0=no;1=yes) 1

FDA
NDA 212801 (label) INN (OSILODROSTAT PHOSPHATE) ISTURISA (RECORDATI RARE) APPROVAL= AP YEAR= 2020 NEWMOLECULARENTITY