e-Drug3D

1971

RIMEGEPANT

INN
RIMEGEPANT

cas 1289023-67-1

CLASS

NERVOUS SYSTEM
TREATMENT OF MIGRAINE WITH OR WITHOUT AURA
A CALCITONIN GENE-RELATED PEPTIDE RECEPTOR ANTAGONIST

ROUTE (list)

ORAL

ATC code

N02CD06

PK parameters

F 64 PERCENT
Tmax 1.5 HOUR
VD 120 LITER
PPB 96 PERCENT
t1/2 11 HOUR

Solubility

SLIGHTLY SOLUBLE IN WATER

Target

TARGET CALCITONIN GENE-RELATED PEPTIDE RECEPTOR

DrugCentral

Calcitonin gene-related peptide type 1 receptor UNIPROT Q16602 CALCRL

Download SDF file

1-Piperidinecarboxylic acid, 4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-, (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl ester

Formula:
C28H28F2N6O3

Calculated chemical properties:

MW 534.56
NB_atoms 39
XLogP 4.49
PSA 95.166
NB_HD 3
NB_HA 9
fsp3 0.36
Lipinski(0=no;1=yes) 0

FDA
NDA 212728 (pdf not found) INN (RIMEGEPANT SULFATE) NURTEC ODT (PFIZER) APPROVAL= AP YEAR= 2020 NEWMOLECULARENTITY