e-Drug3D

1964

SELINEXOR

INN
SELINEXOR

cas 1393477-72-9

CLASS

ANTINEOPLASTIC
NUCLEAR EXPORT EXPORTIN 1 (XPO1) INHIBITOR
IN COMBINATION WITH DEXAMETHASONE
TREATMENT OF REFRACTORY MULTIPLE MYELOMA (RRMM)

ROUTE (list)

ORAL

ATC code

L01XX66

PK parameters

Tmax 4 HOUR
VD 125 LITER
Cl 17.9 LITER / HOUR
PPB 95 PERCENT
t1/2 7 HOUR

Target

TARGET EXPORTIN 1 (XPO1)

Exportin-1 UNIPROT O14980 XPO1

Download SDF file

2-Propenoic acid, 3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, 2-(2-pyrazinyl)hydrazide, (2Z)-

Formula:
C17H11F6N7O

Calculated chemical properties:

MW 443.33
NB_atoms 31
XLogP 3.39
PSA 84.29
NB_HD 2
NB_HA 8
fsp3 0.12
Lipinski(0=no;1=yes) 1

FDA
NDA 212306 (label) INN (SELINEXOR) XPOVIO (KARYOPHARM THERAPS) APPROVAL= AP YEAR= 2019 NEWMOLECULARENTITY