e-Drug3D

1961

FLORTAUCIPIR

INN
FLORTAUCIPIR

cas 1522051-90-6

CLASS

VARIOUS
RADIOACTIVE DIAGNOSTIC AGENT
PET IMAGING OF THE BRAIN
ESTIMATES THE DENSITY AND DISTRIBUTION OF AGGREGATED TAU NEUROFIBRILLARY TANGLES (NFTS) (KD = 0.57 NM)
BIND WITH LOW NANOMOLAR AFFINITY TO MONOAMINE OXIDASE-A AND MONOAMINE OXIDASE-B

ROUTE (list)

INTRAVENOUS

ATC code

V09AX07

PK parameters

Target

TARGET AGGREGATED TAU NEUROFIBRILLARY TANGLES

PDB
8BYN (CHRONIC TRAUMATIC ENCEPHALOPATHY TAU FILAMENTS WITH PET LIGAND FLORTAUCIPIR)

Ligand code = S9C (link to the list of PDB complexes)

Download experimental 3D coordinates of S9C with added hydrogens

DrugCentral

Microtubule-associated protein tau UNIPROT P10636

Download SDF file

5H-Pyrido[4,3-b]indole, 7-[6-(fluoro-18F)-3-pyridinyl]-

Formula:
C16H10FN3

Calculated chemical properties:

MW 263.27
NB_atoms 20
XLogP 3.92
PSA 34.452
NB_HD 1
NB_HA 3
fsp3 0.00
Lipinski(0=no;1=yes) 1

FDA
NDA 212123 (label) INN (FLORTAUCIPIR F-18) TAUVID (AVID RADIOPHARMS INC) APPROVAL= AP YEAR= 2020 NEWMOLECULARENTITY