e-Drug3D

1958

FENFLURAMINE

INN
FENFLURAMINE

cas 458-24-2

CLASS

NERVOUS SYSTEM
TREATMENT OF SEIZURES ASSOCIATED WITH DRAVET SYNDROME
INCREASE EXTRACELLULAR LEVELS OF SEROTONIN THROUGH INTERACTION WITH SEROTONIN TRANSPORTER PROTEINS
EXHIBIT AGONIST ACTIVITY AT SEROTONIN 5HT-2 RECEPTORS

ROUTE (list)

ORAL

ATC code

A08AA02
N03AX26

PK parameters

F 71 PERCENT
Tmax 4.5 HOUR
VD 773.5 LITER (65 KILOGRAM)
Cl 24.8 LITER / HOUR
PPB 50 PERCENT
t1/2 20 HOUR

Target

TARGET SEROTONIN TRANSPORTER

DrugCentral

Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4

Download SDF file

Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)-

Formula:
C12H16F3N

Calculated chemical properties:

MW 231.26
NB_atoms 16
XLogP 3.25
PSA 11.874
NB_HD 1
NB_HA 1
fsp3 0.50
Lipinski(0=no;1=yes) 1

FDA
NDA 212102 (label) INN (FENFLURAMINE HYDROCHLORIDE) FINTEPLA (UCB INC) APPROVAL= AP YEAR= 2020
NDA 216108 (pdf not found) INN (FENFLURAMINE) FENFLURAMINE (APOTEX INC) APPROVAL= TA YEAR= 2024