e-Drug3D

1952

DIROXIMEL

INN
DIROXIMEL

cas 1577222-14-0

CLASS

IMMUNOSUPPRESSANTS
TREATMENT OF MULTIPLE SCLEROSIS (MS)
ACTIVE METABOLITE MONOMETHYL FUMARATE (MMF) ACTIVATES NUCLEAR FACTOR (ERYTHROID-DERIVED 2)-LIKE 2 (NRF2) PATHWAY

ROUTE (list)

ORAL

ATC code

L04AX07

PK parameters

Solubility

SLIGHTLY SOLUBLE IN WATER

Target

DrugCentral

Kelch-like ECH-associated protein 1 UNIPROT Q14145 KEAP1

Download SDF file

2-Butenedioic acid (2E)-, 1-[2-(2,5-dioxo-1-pyrrolidinyl)ethyl] 4-methyl ester

Formula:
C11H13NO6

Calculated chemical properties:

MW 255.22
NB_atoms 18
XLogP -0.59
PSA 90.167
NB_HD 0
NB_HA 7
fsp3 0.45
Lipinski(0=no;1=yes) 1

FDA
NDA 211855 (pdf not found) INN (DIROXIMEL FUMARATE) VUMERITY (BIOGEN INC) APPROVAL= AP YEAR= 2019